Magnetic nanoparticles of zinc and calcium for magnetic hyperthermia application

Authors

  • Rosario Argentina Jasso-Terán Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, CINVESTAV-Unidad Saltillo (Coahuila, México).
  • Dora Alicia Cortés-Hernández Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, CINVESTAV-Unidad Saltillo (Coahuila, México).
  • Héctor Javier Sánchez-Fuentes Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, CINVESTAV-Unidad Saltillo (Coahuila, México).
  • Pamela Yajaira Reyes-Rodríguez Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, CINVESTAV-Unidad Saltillo (Coahuila, México).
  • Laura Elena León-Prado Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, CINVESTAV-Unidad Saltillo (Coahuila, México).

DOI:

https://doi.org/10.19053/01211129.4632

Keywords:

biomaterials, magnetic hyperthermia, simulated body fluid, zinc and calcium ferrites

Abstract

Cancer is the second cause of death in the world. Magnetic hyperthermia is an alternative treatment which consists of raising the temperature of cancer cells using magnetic nanoparticles. In this work, the synthesis and characterization of two calcium-zinc ferrites (Zn0.50Ca0.50Fe2O4 y Zn0.25Ca0.75Fe2O4) are presented. These ferrites were synthesized by sol-gel method, afterwards they were calcined at 400 °C. The saturation magnetization values were 31.31 and 38.30 emu/g for Zn0.50Ca0.50Fe2O4 (ZCF050) and Zn0.25Ca0.75Fe2O4 (ZCF075, respectively. The average particle size was 14 nm for ZCF050 and 12 nm for ZCF075. Additionally, in vitro bioactivity assessment was performed by immersing samples in simulated body fluid (SBF) for 21 days under physiological conditions of pH and temperature. Only the ZCF075 ferrite showed to be bioactive. The heating capacity of ferrites was evaluated under an appropriate magnetic field using solid state magnetic induction. The working conditions were the following: A magnetic field of 10.4 KA/m and a frequency of 362 KHz. The ZCF050 ferrite reached a temperature of 41.2 °C using a concentration of ferrite/water 20 mg/2ml. The ZCF075 ferrite failed to reach 40 °C. The results obtained in the ferrite ZCF050 indicated that these nanoparticles are potential materials for cancer treatment by magnetic hyperthermia therapy.

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References

P. Cherukuri, E. S. Glazer and S. A. Curley, “Targeted hyperthermia using metal nanoparticles,” Advanced drug delivery reviews, vol. 62 (3), pp. 339-345, Mar. 2010. DOI: http://dx.doi.org/10.1016/j.addr.2009.11.006. DOI: https://doi.org/10.1016/j.addr.2009.11.006

A. K. Gupta and M. Gupta, “Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications”, Biomaterials, vol. 26 (18), pp. 3995-4021, Jun. 2005. DOI: http://dx.doi.org/10.1016/j.biomaterials.2004.10.012. DOI: https://doi.org/10.1016/j.biomaterials.2004.10.012

A. Tampieri, T. D’Alessandro, M. Sandri et al., “Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite”, Acta biomaterialia, vol. 8 (2), pp. 843-851, Feb. 2012. DOI: http://dx.doi.org/10.1016/j.actbio.2011.09.032. DOI: https://doi.org/10.1016/j.actbio.2011.09.032

C. S. Kumar and F. Mohammad, “Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery”, Advanced drug delivery reviews, vol. 63 (9), pp. 789-808, Aug. 2011. DOI: http://dx.doi.org/10.1016/j.addr.2011.03.008. DOI: https://doi.org/10.1016/j.addr.2011.03.008

M. Gharagozlou, “Synthesis, characterization and influence of calcination temperature on magnetic properties of nanocrystalline spinel Co-ferrite prepared by polymeric precursor method”, Journal of Alloys and Compounds, vol. 486 (1-2), pp. 660-665, Nov. 2009. DOI: http://dx.doi.org/10.1016/j.jallcom.2009.07.025. DOI: https://doi.org/10.1016/j.jallcom.2009.07.025

K. Maaz, S. Karim, A. Mumtaz et al., “Synthesis and magnetic characterization of nickel ferrite nanoparticles prepared by co-precipitation route”, Journal of Magnetism and Magnetic Materials, vol. 321 (12), pp. 1838-1842, Jun. 2009. DOI: http://dx.doi.org/10.1016/j.jmmm.2008.11.098. DOI: https://doi.org/10.1016/j.jmmm.2008.11.098

W. Yan, W. Jiang, Q. Zhang, Y. Li and H. Wang, “Structure and magnetic properties of nickel–zinc ferrite microspheres synthesized by solvothermal method”, Materials Science and Engineering B, vol. 171 (1-3), pp. 144-148, Jul. 2010. DOI: http://dx.doi.org/10.1016/j.mseb.2010.03.088. DOI: https://doi.org/10.1016/j.mseb.2010.03.088

V. Figueroa-Espí, A. Alvarez-Paneque, M. Torrens, A. Otero-González and E. Reguera, “Conjugation of manganese ferrite nanoparticles to an anti Sticholysin monoclonal antibody and conjugate applications”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol. 387 (1-3), pp. 118-124, Aug. 2011. DOI: http://dx.doi.org/10.1016/j.colsurfa.2011.08.008. DOI: https://doi.org/10.1016/j.colsurfa.2011.08.008

E. Múzquiz-Ramos, D. A. Cortés-Hernández, O. Herrera-Romero and J. C. Escobedo-Bocardo, “Preparation and properties of CoFe2O4 synthesized by the modified citrategel method”, Materials Science Forum, vol. 644, pp. 39-42, Mar. 2010. DOI: http://dx.doi.org/10.4028/www.scientific.net/MSF.644.39. DOI: https://doi.org/10.4028/www.scientific.net/MSF.644.39

T. Kokubo and H. Takadama, “How useful is SBF in predicting in vivo bone bioactivity?”, Biomaterials, vol. 27 (15), pp. 2907-2915, May. 2006. DOI: http://dx.doi.org/10.1016/j.biomaterials.2006.01.017. DOI: https://doi.org/10.1016/j.biomaterials.2006.01.017

I. Sharifi, H. Shokrollahi and S. Amiri, “Ferritebased magnetic nanofluids used in hyperthermia applications”, Journal of Magnetism and Magnetic Materials, vol. 324 (6), pp. 903-915, Mar. 2012. DOI: http://dx.doi.org/10.1016/j.jmmm.2011.10.017. DOI: https://doi.org/10.1016/j.jmmm.2011.10.017

E. M. Múzquiz-Ramos, D. A. Cortés-Hernández and J. C. Escobedo Bocardo, “Biomimetic apatite coating on magnetite particles”, Materials Letters, vol. 64 (9), pp. 1117-1119, May. 2010. DOI: http://dx.doi.org/10.1016/j.matlet.2010.02.025. DOI: https://doi.org/10.1016/j.matlet.2010.02.025

R. L. Avitia, A. Vera and L. Leija. “Estudios de la elevación de temperatura inducida por ferrofluidos en sustitutos de tejido biológico”, XII Seminario Anual de Automática, Electrónica Industrial e Instrumentación, Universidad de Oviedo, pp. 515-519, 2006.

Published

2016-05-03

How to Cite

Jasso-Terán, R. A., Cortés-Hernández, D. A., Sánchez-Fuentes, H. J., Reyes-Rodríguez, P. Y., & León-Prado, L. E. (2016). Magnetic nanoparticles of zinc and calcium for magnetic hyperthermia application. Revista Facultad De Ingeniería, 25(42), 89–98. https://doi.org/10.19053/01211129.4632

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