Manufacture of titanium dioxide scaffolds for medical applications

Elaboración de scaffolds de dióxido de titanio para aplicaciones médicas

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Cuervo-Osorio, G., Jiménez-Valencia, A. M., Mosquera-Agualimpia, C., & Escobar-Sierra, D. M. (2018). Manufacture of titanium dioxide scaffolds for medical applications. Revista Facultad de Ingeniería, 27(48), 17–25. https://doi.org/10.19053/01211129.v27.n48.2018.8017
Published: May 15, 2018
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https://doi.org/10.19053/01211129.v27.n48.2018.8017
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Vol. 27 No. 48 (2018)
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Papers
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Giovanni Cuervo-Osorio
Universidad de Antioquia (Medellín-Antioquía, Colombia).
Ana María Jiménez-Valencia
Universidad de Antioquia (Medellín-Antioquía, Colombia).
Cristian Mosquera-Agualimpia
Universidad de Antioquia (Medellín-Antioquía, Colombia).
Diana Marcela Escobar-Sierra
Ph. D. Universidad de Antioquia (Medellín-Antioquía, Colombia).

Abstract

The skeletal system is vulnerable to injuries and bone loss over the years, making the use of autologous or allogeneic implants necessary. However, these implants have complications, such as the limited amount of bone to be extracted and the cell death at the extraction site; hence, biomaterials have been developed as platforms for cell growth (scaffolds). Biomaterials and bones have similar properties that facilitate the integration between the material and the bone tissue, helping the tissue to regenerate. Traditional ceramic implants are hydroxyapatite, but given their low mechanical properties, they have been replaced with better inert ceramics. Therefore, this study aims at manufacturing titanium dioxide scaffolds through various techniques, using collagen, polyvinyl alcohol (PVA), sodium chloride, and corn flour as binders to influence pore size. Scaffolds were characterized by a Scanning Electron Microscope (SEM) and evaluated by compression and degradability tests in a Simulated Body Fluid (SBF). The prepared scaffolds had mechanical behaviors with ranges within the bone parameters; among them, the scaffold obtained by infiltration with 10% PVA presented values of compression strength (6.75 MPa), elastic modulus (0.23 GPa), and porosities (54-67%) closer to the values of the trabecular bone.

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References (SEE)

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