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Discovering the Spread Patterns of SARS-CoV-2 in Metropolitan Areas

Abstract

The spread of COVID-19 has been extensively studied, but the intricate dynamics of its transmission in interdependent and segregated urban areas, constrained by mobility restrictions, have not been completely understood yet. The pandemic's dynamic-adaptive nature implies that virus spread is influenced by diverse factors operating disparately in urban areas with distinct roles. This study investigates the dynamic spread patterns of COVID-19 in the Santiago Metropolitan Area (SMA), Chile, leveraging explanatory variables related to urban mobility, socio-spatial characteristics, segregation, and sanitary measures. Using publicly available mobility data, we used two indices—the Internal Mobility Index (capturing individual trips within a city’s commune), and the External Mobility Index (indicating trips crossing commune borders). These indices were derived from geolocation data recorded by the cellular telephone antenna network of the Telefónica company by tracking successive antenna transitions during trips. The analysis encompasses a three-stage pandemic pattern, corresponding to periods before, during, and after an initial lockdown in the pandemic's first year. Elastic-Net-Penalty regression models, skillful in both feature selection and managing highly correlated predictors while maintaining the interpretability of the models, are used. These models employ a combination of L1 (ridge) and L2 (lasso) regularized log-likelihood optimization. The ridge penalty functions by contracting the coefficients of correlated predictors, pulling them closer to each other. In contrast, the lasso method tends to choose one predictor and exclude the others. The analysis with these models unveils influences of various explanatory variable subsets throughout the pandemic. Importantly, the study provides evidence justifying the suboptimal outcomes of the dynamic quarantine imposed by authorities. Mobility restrictions were implemented without considering the intricate contextual factors, thus impacting vulnerable areas of the city adversely.

Keywords

Time-varying regression models, City dynamics, COVID-19 spread dynamics, elastic-net regularization, socio-spatial mobility indicators

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References

  1. G. Mena, P. P. Martinez, A. S. Mahmud, P. A. Marquet, C. O. Buckee, M. Santillana, "Socioeconomic status determines COVID-19 incidence and related mortality in Santiago, Chile," Science, vol. 372, no. 6541, pp. 1-9, Apr. 2021. https://doi.org/10.1126/science.abg5298
  2. C. R. Wanberg, B. Csillag, R. P. Douglass, L. Zhou, M. S. Pollard, "Socioeconomic status and well-being during COVID-19: A resource-based examination," Journal of Applied Psychology, vol. 105, no. 12, pp. 1383-1401, Dec. 2020. https://doi.org/10.1037/apl0000831
  3. A. van Dorn, R. E. Cooney, M. L. Sabin, "COVID-19 exacerbating inequalities in the US," Lancet, vol. 395, no. 10232, pp. 1243-1244, Apr. 2020. https://doi.org/10.1016/S0140-6736(20)30893-X
  4. G. Pullano, E. Valdano, N. Scarpa, S. Rubrichi, V. Colizza, "Evaluating the effect of demographic factors, socioeconomic factors, and risk aversion on mobility during the COVID-19 epidemic in France under lockdown: a population-based study," Lancet Digital Health, vol. 2, no. 4, pp. e193-e204, Apr. 2020. https://doi.org/10.1016/S2589-7500(20)30243-0
  5. J. Zhang, B. Feng, Y. Wu, P. Xu, R. Ke, N. Dong, "The effect of human mobility and control measures on traffic safety during COVID-19 pandemic," PLoS One, vol. 16, no. 2, e0243263, Feb. 2021. https://doi.org/10.1371/journal.pone.0243263
  6. J. N. Hays, Epidemics and Pandemics. Their impacts on human history, Denver, Oxford, 2005.
  7. World Health Organization, The economics of social determinants of health and health inequalities. A resource book, Luxembourg, 2013.
  8. L. A. Taylor et al., "Leveraging the social determinants of health: What works?," PLoS One, vol. 11, no. 12, pp. 1-20, Dec. 2016. https://doi.org/10.1371/journal.pone.0160217
  9. M. Cetron, J. Landwirth, "Public health and ethical considerations in planning for quarantine," Yale Journal of Biology and Medicine, vol. 78, no. 5, pp. 329-334, 2005.
  10. P. Bajardi et al., "Human mobility networks, travel restrictions, and the global spread of 2009 H1N1 pandemic," PLoS One, vol. 6, no. 1, e16591, Jan. 2011. https://doi.org/10.1371/journal.pone.0016591
  11. V. Colizza, A. Vespignani, "Epidemic modeling in metapopulation systems with heterogeneous coupling pattern: Theory and simulations," Journal of Theoretical Biology, vol. 251, no. 3, pp. 450-467, May 2008. https://doi.org/10.1016/j.jtbi.2007.11.028
  12. F. F. Feitosa, G. Câmara, A. M. V. Monteiro, T. Koschitzki, M. P. S. Silva, "Global and local spatial indices of urban segregation," International Journal of Geographical Information Science, vol. 21, no. 3, pp. 299-323, Mar. 2007. https://doi.org/10.1080/13658810600911903
  13. F. Sabatini et al., "Promotores inmobiliarios, gentrificación y segregación residencial en Santiago de Chile," Revista Mexicana de Sociología, vol. 79, no. 2, pp. 317-343, Apr. 2017. https://doi.org/10.22201/iis.01882503p.2017.2.57662
  14. R. Truffello, R. Hidalgo, "Policentrismo en el Área Metropolitana de Santiago de Chile: reestructuración comercial, movilidad y tipificación de subcentros," EURE, vol. 41, no. 122, pp. 49-73, Jul. 2015.
  15. Lowy Institute, Covid Performance Index - 13 March, 2021. https://interactives.lowyinstitute.org/features/covid-performance/.
  16. J. Walsh, Covid is Surging in Chile Despite High Vaccination Rates — Here’s Why The U.S. Should Take Notice, 2021.
  17. B. Espinoza et al., "Mobility restrictions for the control of epidemics: When do they work?," PLoS One, vol. 15, no. 7, e0235731, Jul. 2020.
  18. R. M. Anderson et al., "How will country-based mitigation measures influence the course of the COVID-19 epidemic?," Lancet, vol. 395, no. 10228, pp. 931-934, Mar. 2020. https://doi.org/10.1016/S0140-6736(20)30567-5
  19. J.-F. Vergara-Perucich, J. Correa-Parra, C. Aguirre-Nuñez, "The Spatial correlation between COVID-19 propagation and vulnerable urban areas in Santiago de Chile," Critical Housing Analysis, vol. 7, no. 2, pp. 21-35, 2020. https://doi.org/10.13060/23362839.2020.7.2.512
  20. N. Gozzi et al., "Estimating the effect of social inequalities in the mitigation of COVID-19 across communities in Santiago de Chile," medRxiv, 2020. https://doi.org/10.1101/2020.10.08.20204750
  21. M. Herrera, A. Godoy-Faúndez, "Exploring the Roles of Local Mobility Patterns, Socioeconomic Conditions, and Lockdown Policies in Shaping the Patterns of COVID-19 Spread," Future Internet, vol. 13, no. 5, e112, May 2021. https://doi.org/10.3390/fi13050112
  22. Ministerio de Ciencias, Repositorio de Datos COVID-19 en Chile. https://github.com/MinCiencia/Datos-COVID19/blob/master/output/producto1/Covid-19.csv.
  23. H. Zou, T. Hastie, "Regularization and variable selection via the elastic net," Journal of the Royal Statistical Society: Series B, vol. 67, no. 2, pp. 301-320, Apr. 2005. https://doi.org/10.1111/j.1467-9868.2005.00503.x
  24. Ministerio de Transporte de Chile, O-D matrices, 2020. http://www.dtpm.gob.cl/index.php/documentos/matrices-de-viaje.
  25. M. A. Munizaga, C. Palma, "Estimation of a disaggregate multimodal public transport Origin–Destination matrix from passive smartcard data from Santiago, Chile," Transportation Research Part C: Emerging Technologies, vol. 24, pp. 9-18, Jun. 2012. https://doi.org/10.1016/j.trc.2012.02.002
  26. L. Hufnagel et al., "Forecast and control of epidemics in a globalized world," Proceedings of the National Academy of Sciences, vol. 101, no. 42, pp. 15124-15129, Oct. 2004. https://doi.org/10.1073/pnas.0308344101
  27. J. Sun et al., "Population flow drives spatio-temporal distribution of COVID-19 in China," Nature, vol. 582, no. 7812, pp. 389-394, Jun. 2020. https://doi.org/10.1038/s41586-020-2284-y
  28. M. Batty, "Agents, Cells, and Cities: New Representational Models for Simulating Multiscale Urban Dynamics," Environment and Planning A: Economy and Space, vol. 37, no. 8, pp. 1373-1394, Aug. 2005. https://doi.org/10.1068/a3784
  29. H. Lefebvre, D. Nicholson-Smith, The Production of Space, Wiley-Blackwell, 1992.
  30. C. Boano, G. Talocci, "The (in) Operative Power: Architecture and the Reclaim of Social Relevance," STUDIO Magazine, no. 6, 2014.
  31. D. A. Edwards et al., "Exhaled aerosol increases with COVID-19 infection, age, and obesity," Proceedings of the National Academy of Sciences, vol. 118, no. 8, Feb. 2021. https://doi.org/10.1073/pnas.2021830118
  32. CDC, Science Brief: SARS-CoV-2 Transmission, 2019. https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/sars-cov-2-transmission.html
  33. J. K. Tay, B. Narasimhan, T. Hastie, "Elastic Net Regularization Paths for All Generalized Linear Models," Journal of Statistical Software, vol. 106, no. 1, pp. 1–31, 2023. https://doi.org/10.18637/jss.v106.i01
  34. Ministerio de Ciencias, Repositorio de Datos COVID-19 en Chile. Datos Covid-19 (2021), https://github.com/MinCiencia/Datos-COVID19/tree/master/output/producto33.
  35. IDE Observatorio de Ciudades UC. https://observatoriodeciudades.com

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