EVALUACIÓN DEL EFECTO DE LA SUPLEMENTACIÓN CON PÉPTIDOS DE COLÁGENO Y ÁCIDO ASCÓRBICO SOBRE EL URIANALISIS DE CANINOS
Abstract
Bioactive peptides have considerable health-promoting properties in animals. The effects of supplementation of collagen peptides and vitamin C (PolyPet®) on uroanalysis were evaluated in a total of 24 canines randomly selected in three groups (control group, group 1 and group 2). The treatments consisted of daily supplementation with PolyPet® , group 1 with 6.6 g, group 2 with 3.3 g and the control group without any supplementation. Urine samples were taken at days 0, 30 and 60 from the canines in the study. The uroanalysis parameters evaluated were protein, ascorbic acid, urinary protein/urinary creatinine ratio (UP/UC), nitrites, specific gravity, crystalluria, pH, calciuria, odor, creatinuria and body weight. For the presence of crystals there was no significant difference between the three groups. For amorphous urates and uric acid crystals, an increase was evidenced with the supplementation of porcine collagen peptide and the variables triple phosphate, struvite crystals and weight decrease were positively affected with the supplementation. The use of collagen peptides and vitamin C (PolyPet®) showed positive effects on canine health, being considered a safe food for healthy individuals.
Keywords
amino acids, collagen, nutraceuticals, partial urine, vitamin c
Author Biography
CARLOS EDUARDO RODRIGUEZ MOLANO
Zootecnista, Universidad Nacional de Colombia, Especialista en Bioquímica, Investigación y Docencia, Magister en Ciencias Biológicas, Profesor Asociado Universidad Pedagógica y Tecnológica de Colombia. Coordinador Grupo de Investigacion en Bioquimica y Nutrición Animal
References
- S. Rojas-Jiménez, "Consumo de nutracéuticos, una alternativa en la prevención de las enfermedades crónicas no transmisibles,” Biosalud, vol. 14 (2), pp. 91-103, 2015. https://doi.org/10.17151/biosa.2015.14.2.9
- M. Abdel-Hamid, J. Otte, C. De Gobba, A. Osman, A. Hamad, "Angiotensin I-converting enzyme inhibitory activity and antioxidant capacity of bioactive peptides derived from enzymatic hydrolysis of buffalo milk proteins", Int. Dairy J, vol, 66, pp. 91-98, 2017. https://doi.org/10.1016/j.idairyj.2016.11.006.
- S. Chakrabarti, F. Jahandideh, J.Wu, "Food-derived bioactive peptides on inflammation and oxidative stress. Biomed Res, vol 2014, 2014. https://doi.org/10.1155/2014/608979.
- E. Shakeri, H. Oskoueian, H. Le, M. Shakeri, "Strategies to combat heat stress in broiler chickens: Unveiling the roles of selenium, vitamin E and vitamin C",Vet. Sci, vol. 7(2), pp. 1-9, 2020. C10.3390/VETSCI7020071.
- C. Rizzello, D. Tagliazucchi, E. Babini, G. Sefora-Rutella, D. Taneyo-Saa, A. Gianotti, "Bioactive peptides from vegetable food matrices: Research trends and novel biotechnologies for synthesis and recovery", J. Funct. Foods, vol, 27, pp. 549-569, 2016. https://doi.org/10.1016/j.jff.2016.09.023.
- M. Schunck, H. Louton, S. Oesser, "The Effectiveness of Specific Collagen Peptides on Osteoarthritis in Dogs-Impact on Metabolic Processes in Canine Chondrocytes", Open J. Anim. Sci, vol 07(03), pp. 254-266, 2017. https://doi.org/10.4236/ojas.2017.73020.
- E. Daliri, D. Oh, H. Lee, "Bioactive peptides", Foods, vol 6(5), pp. 1-2, 2017. https://doi.org/10.3390/foods6050032.
- J. Santos, M. Krutzmann, C. Bierhals, L. Feksa. "The effects of supplementation with Vitamin C", Rev. Conhecimento Online; vol. 1, pp. 139-163, 2019. https://doi.org/10.25112/rco.v1i0.1187.
- S. Rangarajan, L. Bhuvana-Sunil, "Ascorbic Acid in Cancer: A Renewed Hope?", J. Cancer Sci. Ther, vol. 06(09), pp. 333-336, 2014. https://doi.org/10.4172/1948-5956.1000291.
- H. Izumi, et al. "Α-Lactalbumin Hydrolysate Stimulates Glucagon-Like Peptide-2 Secretion and Small Intestinal Growth in Suckling Rats,", J. Nutr, vol. 139(7), pp. 1322-1327, 2009. https://doi.org/10.3945/jn.109.106401.
- A. Bessone, et al. "Evaluación clínica y bioquímica de perros mayores de 8 años con factores de riesgo para desarrollar enfermedad renal crónica. Resultados preliminares", Cienc. Vet, vol. 21(2), pp. 29-42, 2019. Available: https://cerac.unlpam.edu.ar/index.php/veterinaria/article/view/4278/4559%0Ahttps://cerac.unlpam.edu.ar/index.php/veterinaria/article/view/4278
- S. Yadav, N. Ahmed, A. Nath, D. Mahanta, M. Kalita, "Urinalysis in dog and cat: A review". Vet. World, vol. 13(10), pp. 2133-2141, 2020. https://doi.org/10.14202/vetworld.2020.2133-2141.
- J. Delanghe, M. Speeckaert, "Preanalytical requirements of urinalysis", Biochem. Medica, vol. 24(1), pp. 89-104, 2014. https://doi.org/10.11613/BM.2014.011.
- H. Tvedten, I. Lilliehöök, H. Rönnberg, L. Pelander, "Massive uric acid crystalluria and cylinduria in a dog after l-asparaginase treatment for lymphoma", Vet. Clin. Pathol, vol 48(3), pp. 425-428. https://doi.org/10.1111/vcp.12719.
- S. Chamsuwan, et al. "A urinary proteomic study in hypercalciuric dogs with and without calcium oxalate urolithiasis", Vet. World, vol. 15(12), pp. 2937-2944, 2022. https://doi.org/10.14202/vetworld.2022.2937-2944.
- C. Goloni, B. Bonder, S. Senhorello, M. Tinucci-Costa, A. Carciofi, "Dissolução De Urólito De Estruvita Por Meio De Manejo Nutricional E Antibioticoterapia Em Cão: Relato De Caso", Ars Vet, vol. 34(3), pp. 135, 2018. https://doi.org/10.15361/2175-0106.2018v34n3p135-140.
- E. Polat, E. Kaya, M. Oral, N. Çelikdemir, "Microscopic evaluation and Descriptive study of Crystals and Uroliths encountered in the Urinary tract system of Cats and Dogs", Rev. Científica la Fac. Ciencias Vet,: vol. XXXII, pp. 1-8, 2022. https://doi.org/10.52973/rcfcv-e32166.
- F. Manrique-Abril, J. Rodríguez-Díaz, J. Ospina-Díaz, "Rendimiento diagnóstico del parcial de orina como predictor de infección urinaria en pacientes de Tunja, Colombia", CES Medicina, vol. 28(1), pp. 21-34, 2014.
- C. Finno, "Veterinary Pet Supplements and Nutraceuticals", Nutr. Today, vol 55(2), pp. 97-101, 2020. https://doi.org/10.1097/NT.0000000000000399.
- J. Santos, et al. "Inclusion of Yucca schidigera extract and zeolite in the diet and its relationship to the apparent digestibility of nutrients and urinary pH in adult dogs". Ciência Rural, vol. 46(8), pp. 1456-1459, 2016. https://doi.org/10.1590/0103-8478cr20140386.
- E. Vasquez, A. Kendall, S. Musulin, S. Vaden, "Three-dimensional bladder ultrasound to measure daily urinary bladder volume in hospitalized dogs", J. Vet. Intern. Med, vol. 35(5), pp. 2256-2262, 2021. https://doi.org/10.1111/jvim.16232.
- M. Abdulrahman, S. Arbab, M. Ali, A. Rushdi, M. Gar-Elnabi, "Characterization of Kidney Disease in Adults’ Patients Using Ultrasonography", Sch. J. Appl. Med. Sci, vol 9(3), pp. 372-377, 2021. https://doi.org/10.36347/sjams.2021.v09i03.015.
- E. Bijsmans, V. Quéau, V. Biourge, "Increasing dietary potassium chloride promotes urine dilution and decreases calcium oxalate relative supersaturation in healthy dogs and cats" Animals, vol. 11(6), 2021. https://doi.org/10.3390/ani11061809.
- J. Rodriguez, C. Cora, M. Gines, G. Schröder, "La evaluación bioquímica de la proteinuria de caninos en el laboratorio de análisis clínicos veterinarios" Analecta Vet, vol. 40(1), pp. 044, 2020. https://doi.org/10.24215/15142590e044.
- H. Tvedten, "Urine total protein concentration in clinically normal dogs", Vet. Clin. Pathol, vol. 45(3), pp. 395-396, 2016. https://doi.org/10.1111/vcp.12379.
- G. Ko, K. Rhee, K. Kalantar-Zadeh, S. Joshi, "The effects of high-protein diets on kidney health and longevity", J. Am. Soc. Nephrol, vol. 31(8), pp. 1667-1679, 2020. https://doi.org/10.1681/ASN.2020010028.
- A. Aparicio, E. Nebot, "Medicina del deporte", Acta Médica Colomb, vol. 43(2S), pp. 176, 2019. https://doi.org/10.36104/amc.2018.1400.
- R. Major, "Clinical assessment of kidney function and prognosis in adults", Med. (United Kingdom), vol. 51(2), pp. 98-101, 2023. https://doi.org/10.1016/j.mpmed.2022.11.009.
- E. Martello, et al. "Efficacy of a new dietary supplement in dogs with advanced chronic kidney disease", PeerJ, vol 8, 2020. https://doi.org/10.7717/peerj.9663.
- X.,Li et al, "Efficacy of low-protein diet in diabetic nephropathy: A meta-analysis of randomized controlled trials", Lipids Health Dis, vol. 18(1), pp. 1-9, 2019. https://doi.org/10.1186/s12944-019-1007-6.
- L. Mejía, H. García-Perdomo, R. Contreras, "Manejo dietario para la prevención de urolitiasis", Urol. Colomb, vol. 23(3), pp. 214-218, 2014. https://doi.org/10.1016/S0120-789X(14)50059-7.
- J. Lulich, A. Berent, L. Adams, J. Westropp, J. Bartges, C. Osborne, "ACVIM Small Animal Consensus Recommendations on the Treatment and Prevention of Uroliths in Dogs and Cats", J. Vet. Intern. Med, vol. 30(5), pp. 1564-1574, 2016. https://doi.org/10.1111/jvim.14559.
- C. Okafor, et al. In dogs evaluated at general care veterinary hospitals in the United States. J. Am. Vet. Med. Assoc 2013;243(12):1737-1745.
- A. Chaudhury, et al, "Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management", Front. Endocrinol, (Lausanne), vol, 8, 2017. https://doi.org/10.3389/fendo.2017.00006.
- L. Santiago-López, A. Hernández-Mendoza, B. Vallejo-Cordoba, V. Mata-Haro, A. González-Córdova, "Food-derived immunomodulatory peptides" J. Sci. Food Agric, vol. 96(11), pp. 3631–364, 2016. https://doi.org/10.1002/jsfa.7697.
- M. Cline, et al, "AAHA Nutrition and Weight Management Guidelines for Dogs and Cats", J. Am. Anim. Hosp. Assoc, vol. 57(4), pp. 157-178, 2021. https://doi.org/10.5326/JAAHA-MS-7232.
- M. Beerepoot, S. Geerlings, "Non-antibiotic prophylaxis for urinary tract infections", Pathogens, vol. 5(2), 2016. https://doi.org/10.3390/pathogens5020036.
- A. Sharma, A. Singh, J. Kachhawa, S. Gupta, R. Sharma, "Urine analysis of chronic renal failure suffered dogs", Vet. Pract, vol. 21(2), pp. 216-219, 2020.
- A. Negri, F. Spivacow, E. Del Valle, "La dieta en el tratamiento de la litiasis renal bases fisiopatológicas", MEDICINA (Buenos Aires), vol. 73, pp. 267-271, 2013.
- K. Hussain-Reddy, "The Chemistry of Antioxidants. Resonance", vol. 27(4), pp. 641-658, 2022. https://doi.org/10.1007/s12045-022-1354-x