Actividad Antioxidante De Los Musgos Breutelia subdisticha, Leptodontium viticulosoides y Pylaisia falcata
![](https://revistas.uptc.edu.co/public/journals/20/cover_issue_739_es_ES.png)
Resumen
Los musgos son utilizados por muchas culturas para tratar diferentes enfermedades, probablemente por sus compuestos bioactivos, algunos de los cuales pueden presentar actividad antioxidante. Esta investigación evaluó la actividad antioxidante (AA) de Breutelia subdisticha (Hampe) A. Jaeger, Leptodontium viticulosoides (P. Beauv.) Wijk & Margad. y Pylaisia falcata Schimp., a partir de extractos de diclorometano y etanólicos, mediante los métodos 2,2-difenil-1-picrilhidracilo (DPPH*) y ácido 2,2′-azino-bis-3-etilbenzotiazolin-6-sulfónico (ABTS*+). A los extractos obtenidos mediante la técnica Soxhlet se les determinó la concentración inhibitoria (IC50) y la actividad antioxidante relativa (%AAR), con posteriores análisis estadísticos de ANOVA y post-hoc de Tukey. Los extractos etanólicos presentaron mayor capacidad antioxidante que los de diclorometano. Por el método DPPH* los extractos etanólicos mostraron una %AAR respecto al ácido ascórbico de 3.06 para L. viticulosoides, 177.00 para B. subdisticha y 141.66 para P. falcata; mientras que con el método ABTS*+ la %AAR con respecto al ácido ascórbico fue de 1.75 para L. viticulosoides, 139.17 para B. subdisticha y 120.22 para P. falcata. Como conclusión, L. viticulosoides exhibió la mejor actividad antioxidante, por lo cual se sugiere continuar con su investigación y lograr una aplicación farmacológica de origen natural.
Palabras clave
Briófitos, antioxidante, radicales libres, DPPH* y ABTS*
Referencias
- L. Castro, B.A. Freeman, “Reactive Oxygen Species in Human Health and Disease. Science”, Nutrition, vol. 17(2), pp. 161–165, 1954. DOI: 10.1016/s0899-9007(00)00570-0 DOI: https://doi.org/10.1016/S0899-9007(00)00570-0
- I.S. Young, J.V. Woodside, “Antioxidants in health and disease”, Journal of Clinical Pathology, vol. 54, pp. 176-186, 2001. DOI: 10.1136/jcp.54.3.176 DOI: https://doi.org/10.1136/jcp.54.3.176
- B. Halliwell, J.M.C. Gutteridge, “Free Radicals in Biology and Medicine”. United Kingdom: Oxford University Press, 2007.
- R. Mittler, “Oxidative stress, antioxidants and stress tolerance”, Trends in Plant Science, vol. 7(9), pp. 405–410, 2002. DOI:10.1016/s1360-1385(02)02312-9 DOI: https://doi.org/10.1016/S1360-1385(02)02312-9
- A. Thomas-Schoemann, J. Alexandre, C. Mongaret, S. Azibi, A. Dauphin, F. Goldwasser, F. Lemare, “Prise d’antioxydants et d’autres thérapies complémentaires par les patients sous chimiothérapie antitumorale: étude prospective”, Bull Cancer, vol. 98, pp. 645-653, 2011. DOI: 10.1684/bdc.2011.1375 DOI: https://doi.org/10.1684/bdc.2011.1375
- D. Robbins, Y. Zhao, “The Role of Manganese Superoxide Dismutase in Skin Cancer”, Enzyme Research, pp. 1- 7, 2011. DOI:10.4061/2011/409295 DOI: https://doi.org/10.4061/2011/409295
- A. Yadav, R. Kumari, A. Yadav, J.P. Mishra, S. Srivatva, S. Prabha, “Antioxidants and its functions in human body - A Review”, Research in Environment and Life Sciences, vol. 9(11), pp. 1328-1331, 2016.
- S.R. Gradstein, S.P. Churchill, N. Salazar-Allen, “Guide to the Bryophytes of Tropical America”, Editorial Board. New York: Memoirs of the New York Botanical Garden, 2001.
- A. Vanderpoorten, B. Goffinet, “Introduction to Bryophytes”, Cambridge University Press, New York, 2009. DOI: 10.1017/CBO9780511626838 DOI: https://doi.org/10.1017/CBO9780511626838
- M.C.F. Proctor, “Physiological ecology”. In: Goffinet B, Shaw AJ Eds. Bryophyte biology, 2nd edition. Cambridge University Press, Cambridge, pp. 237-268, 2009. DOI:10.1017/cbo9781139171304.009 DOI: https://doi.org/10.1017/CBO9780511754807.007
- B. Estébanez- Pérez, I. Draper Díaz De Atauri, R. Medina- Bujalance, “Briófitos: Una aproximación a las plantas terrestres más sencillas”, Memorias de la Real Sociedad Española de Historia Natural, vol. 2(9), pp. 1-56, 2011.
- A.J. Shaw, P. Szövényi, B. Shaw, “Bryophyte Diversity and Evolution: Windows into the early evolution of lands plants”, American Journal of Botany, vol. 98(3), pp. 352-369, 2011. DOI: 10.3732/ajb.1000316 DOI: https://doi.org/10.3732/ajb.1000316
- C.J. Cox, B. Goffinet, N.J. Wickett, S.B. Boles, A.J. Shaw, “Moss diversity: A molecular phylogenetic analysis of genera”, Phytotaxa, vol. 9, pp. 175-195, 2010. DOI:10.11646/phytotaxa.9.1.10 DOI: https://doi.org/10.11646/phytotaxa.9.1.10
- R. Bernal, S. Gradsteins, and M. Celis, “Catálogo de plantas y líquenes de Colombia”, vol. I. Bogotá, Colmbia: Universidad Nacional de Colombia (Sede Bogotá). Facultad de Ciencias. Instituto de Ciencias Naturales, 2016.
- S. R. Gradstein, “Key to hornworts (Anthocerotophyta) of Colombia”, Caldasia, vol, 40(2), pp. 262-270, 2018. DOI: 10.15446/caldasia.v40n2.71750 DOI: https://doi.org/10.15446/caldasia.v40n2.71750
- S.P. Churchill, E. Linares, “Prodromus Bryologiae Novo- Granatensis: Introducción a la Flora de Musgos de Colombia Parte I”, Editora Guadalupe Ltda, Santa fé de Bogotá, pp. 490, 1995.
- J.M. Glime, “Economic and Ethnic Uses of Bryophytes”, In: Flora of North America Editorial Committee, eds. 1993. Flora of North America North of Mexico. 15+ vols. New York & Oxford, vol. 27, pp. 14-41, 2007.
- S. Flowers, “Ethnobryology of the Gosuite Indians of Utah”, The Bryologist, vol. 60(1), pp. 1-11, 1957. DOI:10.2307/3240044 DOI: https://doi.org/10.2307/3240044
- M.S. Sabovljeviić, A.D. Sabovljeviić, N.K. Ikram, A. Peramuna, H. Bae, H.T. Simonsen, “Bryophytes – an emerging source for herbal remedies and chemical production”, Plant Genetic Resources: Characterization and Utilization, vol. 14(4), pp. 314-327, 2016. DOI:10.1017/S1479262116000320 DOI: https://doi.org/10.1017/S1479262116000320
- O. Tonguç- Yayintaş, “Bryophytes as hidden treasure”, Journal of Scientific Perspectives, vol, 2(1), pp. 71-83, 2018. DOI: 10.26900/jsp.2018.07 DOI: https://doi.org/10.26900/jsp.2018.07
- J.P. Frahm, “Recent Developments of Commercial Products from Bryophytes”, The Bryologist, vol. 107(3), pp. 277-283, 2004. DOI: https://doi.org/10.1639/0007-2745(2004)107[0277:RDOCPF]2.0.CO;2
- G. Montenegro, M. Portaluppi, F.A. Salas, M.F. Díaz, “Biological properties of the Chilean native moss Sphagnum
- magellanicum”, Biological Research, vol. 42, pp. 233-237, 2009. DOI:10.4067/s0716-97602009000200012 DOI: https://doi.org/10.4067/S0716-97602009000200012
- Ö. Ertürk, H. Sahin, E.Y. Ertürk, H.E. Hotaman, B. Koz, Ö. Özdemir, “The antimicrobial and antioxidant activities of extracts obtained from some moss species in Turkey”, Herba Polonica, vol, 61(4), pp. 52-65, 2015. DOI: 10.1515/hepo-2015-0031 DOI: https://doi.org/10.1515/hepo-2015-0031
- A. Dey, J. Nath De, “Antioxidative Potential of Bryophytes: Stress Tolerance and Commercial Perspectives: A Review”, Phannacologia, vol. 3 (6), pp. 151-159, 2012. DOI: 10.5567/pharmacologia.2012.151.159 DOI: https://doi.org/10.5567/pharmacologia.2012.151.159
- A. Dey, A. Mukherjee, “Therapeutic potential of bryophytes and derived compounds against cancer”, Journal of Acute Disease, vol. 4(3), pp. 236-248. 2015. DOI: 10.1016/j.joad.2015.04.011 DOI: https://doi.org/10.1016/j.joad.2015.04.011
- D.K. Saxena, Harinder, “Uses of bryophytes”. Resonance, vol. 9(6), pp. 56-65, 2004. DOI:10.1007/bf02839221 DOI: https://doi.org/10.1007/BF02839221
- Y. Asakawa, “Biologically active compounds from bryophytes*”. Pure and Applied Chemistry, vol. 79(4), pp. 557-580, 2007.
- DOI:10.1351/pac200779040557 DOI: https://doi.org/10.1351/pac200779040557
- E.S.J. Harris, “Ethnobryology: traditional uses and folk classification of bryophytes”, The Bryologist, vol. 111(2), pp. 169-217, 2008. DOI: https://doi.org/10.1639/0007-2745(2008)111[169:ETUAFC]2.0.CO;2
- A. Alam, V. Shrama, K.K. Rawat, P.K. Verma, “Bryophytes - The Ignored Medicinal Plants”, SMU Medical Journal, vol. 2(1), pp. 299-316, 2015.
- Y. Asakawa, A. Ludwiczuk, “Chemical Constituents of Bryophytes: Structures and Biological Activity”, Journal of Natural Products, vol. 81, pp. 641-660, 2018. DOI: 10.1021/acs.jnatprod.6b01046 DOI: https://doi.org/10.1021/acs.jnatprod.6b01046
- M. Saxena, J. Saxena, R. Nema, D. Singh, A. Gupta, “Phytochemistry of Medicinal Plants”, Journal of Pharmacognosy and Phytochemistry, vol. 1(6), pp. 168-182, 2013.
- G.M. Greeshma, G.S. Manoj, K. Murugan, “Insight into pharmaceutical importance of bryophytes”, Kongunadu Research Journal, vol. 4(2), pp. 84-88, 2017. DOI:10.26524/krj208 DOI: https://doi.org/10.26524/krj208
- Y. Asakawa, A. Ludwiczuk, “Bryophytes: Liverworts, Mosses, and Hornworts: Extraction and Isolation Procedures”, Metabolomics Tools for Natural Product Discovery, pp. 1-20, 2013. DOI:10.1007/978-1-62703-577-4_1 DOI: https://doi.org/10.1007/978-1-62703-577-4_1
- Y. Asakawa, “Chemical Constituents of the Bryophytes”, Progress in the Chemistry of Organic Natural Products, pp. 1-562, 1995. DOI:10.1007/978-3-7091-6896-7_1 DOI: https://doi.org/10.1007/978-3-7091-6896-7_1
- H. Geiger, T. Seeger, H. Dietmar- Zinsmeister, J.P. Frahm, “The ocurrence of flavonoids in arthrodontous mosses- An account of the present knowledge”, J. Hattori Bot. Lab. Vol. 83, pp. 273-308, 1997.
- C. Suire, G. Bourgeois, T. Koponen, “Some chemical constituents of thirteen mosses from the traditional Mniaceae family”, Journal of the Hattori Botanical Laboratory, vol. 89, pp. 233-246, 2000.
- Y. Asakawa, “Recent advances in phytochemistry of bryophytes- acetogenins, terpenoids and bis(bibenzyl)s from selected Japanese, Taiwanese, New Zealand, Argentinean and European liverworts”, Phytochemistry, vol. 56(3), pp. 297–312, 2001. DOI:10.1016/s0031-9422(00)00454-4 DOI: https://doi.org/10.1016/S0031-9422(00)00454-4
- C.F. Xie, H.X. Lou, “Secondary Metabolites in Bryophytes: An Ecological Aspect”, Chemistry & Biodiversity, vol. 6(3), pp. 303-312, 2009. DOI:10.1002/cbdv.200700450 DOI: https://doi.org/10.1002/cbdv.200700450
- Y. Asakawa, A. Ludwiczuk, F. Nagashima, “Phytochemical and biological studies of bryophytes”, Phytochemistry, pp. 1-29, 2012. DOI: 10.1016/j.phytochem.2012.04.012 DOI: https://doi.org/10.1016/j.phytochem.2012.04.012
- Y. Asakawa, A. Ludwiczuk, F. Nagashima, “Chemical constituents of bryophytes: bio- and chemical diversity, biological activity, and chemosystematics”, Progress in the Chemistry of Organic Natural Products. Springer, vol. 95, pp. 1-796, 2013. DOI:10.1007/978-3-7091-1084-3 DOI: https://doi.org/10.1002/chin.201312271
- K. Peters, K. Gorzolka, H. Bruelheide, S. Neumann, “Seasonal variation of secondary metabolites in nine different bryophytes”, Ecology and Evolution, vol. 8, pp. 9105-9117, 2018. DOI: 10.1002/ece3.4361 DOI: https://doi.org/10.1002/ece3.4361
- Y. Saritas, M.M. Sonwa, H. Iznaguen, W.A. König, H. Muhle, R. Mues, “Volatile constituents in mosses (Musci)”, Phytochemistry, vol. 57(3), pp. 443-457, 2001. DOI:10.1016/s0031-9422(01)00069-3 DOI: https://doi.org/10.1016/S0031-9422(01)00069-3
- Ivanova V, Kolarova M, Aleksieva K, Dornberger K, Haertl A, Moellmann U, et al., “Sanionins: Anti‐Inflammatory and Antibacterial Agents with Weak Cytotoxicity from the Antarctic Moss Sanionia georgico‐uncinata”, Preparative Biochemistry and Biotechnology, vol. 37(4), pp. 343-352, 2007. DOI:10.1080/10826060701593241 DOI: https://doi.org/10.1080/10826060701593241
- A.O. Adebiyi, A.A. Oyedeji, E.E. Chikwendu, O.A. Fatoke, “Phytochemical Screening of Two Tropical Moss Plants: Thidium gratum P. Beauv and Barbula indica Brid Grown in Southwestern Ecological Zone of Nigeria”, American Journal of Analytical Chemistry, vol. 3, pp. 836-839, 2012. DOI: 10.4236/ajac.2012.312110 DOI: https://doi.org/10.4236/ajac.2012.312110
- J. Cuvertino- Santoni, Y. Asakawa, M. Nour, G. Montenegro, “Volatile Chemical Constituents of the Chilean Bryophytes”, Natural Product Communications, vol. 12(12), pp. 1929-1932, 2017. DOI:10.1177/1934578x1701201229 DOI: https://doi.org/10.1177/1934578X1701201229
- S. Kaur, S. Kapila, I.K. Maurya, “Phytochemical Analysis and Characterization of the Bioactive Compounds of Mnium cuspidatum by GC-MS and FTIR”, International Journal of Life Sciences Research, vol. 7(1), pp. 254-262, 2019.
- G. Zheng, C. Chang, “Ohioensins: novel benzonaphthoxanthenones from Polytrichum ohioense.” Journal of Organic Chemistry, vol. 58, pp. 366-372, 1993. DOI:10.1021/jo00054a019 DOI: https://doi.org/10.1021/jo00054a019
- A. Basile, S. Giordano, J.A. López- Sáez, R.C. Cobianchi, “Antibacterial activity of pure flavonoids isolated from mosses”, Phytochemistry, vol. 52(8), pp. 1479-1482, 1999. DOI:10.1016/s0031-9422(99)00286-1 DOI: https://doi.org/10.1016/S0031-9422(99)00286-1
- S. Ílhan, F. Savaroglu, F. Colak, C. Filik Iscen, F.Z. Erdemgil, “Antimicrobial Activity of Palustriella commutata (Hedw.) Ochyra Extracts (Bryophyta)”, Turkish Journal of Biology, vol. 30, pp. 149-152, 2006.
- M. Veljić, A. Đurić, M. Soković, A. Ćirić, J. Glamočlija, D.P. Marin, “Antimicrobial activity of methanol extracts of fontinalis antipyretica, Hypnum cupressiforme, and Ctenidium molluscum”, Archives of Biological Sciences, vol. 61(2), pp. 225-229, 2009. DOI:10.2298/ABS0901225V DOI: https://doi.org/10.2298/ABS0902225V
- G.S. Deora, D. Suhalka, “Phytochemical Composition and Fungicidal Potential of Moss Philonotis revoluta against Spore Germination Process of Fungus Helminthosporium turcicum”, IOSR Journal of Pharmacy and Biological Sciences, vol. 11(6), pp. 38-43, 2016. DOI: 10.9790/3008-1106033843
- H.D. Bhattarai, B. Paudel, H.S. Lee, Y.K. Lee, J.H. Yim, “Antioxidant activity of Sanionia uncinata, a polar moss species from King George Island, Antarctica”, Phytotherapy Research, vol. 22(12), pp. 1635-1639, 2008. DOI:10.1002/ptr.2538 DOI: https://doi.org/10.1002/ptr.2538
- F.A. Karim, M. Suleiman, A. Rahmat, M.F. Abu- Bakar, “Phytochemicals, antioxidant and antiproliferative properties of five moss species from Sabah, Malaysia”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6(10), pp. 292-297, 2014.
- X. Cheng, Y. Xiao, X. Wang, P. Wang, H. Li, H. Yan, et al., “Anti-tumor and pro-apoptotic activity of ethanolic extract and its various fractions from Polytrichum commune L.ex Hedw in L1210 cells”, Journal of Ethnopharmacology, vol. 143(1), pp. 49-56, 2012. DOI:10.1016/j.jep.2012.05.054 DOI: https://doi.org/10.1016/j.jep.2012.05.054
- V. Chobot, L. Kubicová, S. Nabbout, L. Jahodář, J. Vytlačilová, “Antioxidant and free radical scavenging activities of five moss species”, Fitoterapia, vol. 77(7-8), pp. 598-600, 2006. DOI:10.1016/j.fitote.2006.06.010 DOI: https://doi.org/10.1016/j.fitote.2006.06.010
- V. Chobot, L. Kubicova, S. Nabbout, Jahodár, F. Hadacek, “Evaluation of Antioxidant Activity of Some Common Mosses”, Zeitschrift für Naturforschung, vol. 63c, pp. 476-482, 2008. DOI: 10.1515/znc-2008-7-802 DOI: https://doi.org/10.1515/znc-2008-7-802
- H.D. Bhattarai, B. Paudel, H.K. Lee, H. Oh, J.H. Yim, “In vitro Antioxidant Capacities of Two Benzonaphthoxanthenones: Ohioensins F and G, Isolated from the Antarctic Moss Polytrichastrum alpinum”, Zeitschrift für Naturforschung, vol. 64c, pp. 197-200, 2009. DOI: 10.1515/znc-2009-3-408 DOI: https://doi.org/10.1515/znc-2009-3-408
- S. Talai- Mukhopadhyay, S. Mitra, A. Biswas, N. Das, M. Poddar- Sarkar, “Screening of Antimicrobial and Antioxidative Potential of Selected Eastern Himalayan Mosses”, European Journal of Medicinal Plants, vol. 3(3), pp. 422-428, 2013. DOI: 10.9734/EJMP/2013/3164 DOI: https://doi.org/10.9734/EJMP/2013/3164
- B. Pejin, J. Bogdanovic- Pristov, I. Pejin, M. Sabovljević, “Potential antioxidant activity of the moss Bryum moravicum”, Natural Product Research, vol. 27(10), pp. 900-902, 2013. DOI:10.1080/14786419.2012.665915 DOI: https://doi.org/10.1080/14786419.2012.665915
- R. Mishra, V.K. Pandey, R. Chandra, “Potential of bryophytes as therapeutics”, International Journal of Pharmaceutical Sciences and Research, vol. 5(9), pp. 3584-93, 2014. DOI: 10.13040/IJPSR.0975-8232.5 (9).3584-93
- F. Abdul- Karim, M. Suleiman, A. Rahmat, M.F. Abu- Bakar, “Phytochemicals, antioxidant and antiproliferative properties of five moss species from Sabah, Malaysia”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6(10), pp. 292-297, 2014.
- V. Singh, A. Alam, A. Sharma, “Evaluation of Phytochemicals, Antioxidant and Antibacterial Activity of Hyophila involuta (Hook.) Jaeg. and Entodon plicatus C.Muell. (Bryophyta) from Rajasthan, India”, International Journal of Scientific Research in Knowledge, vol. 4(3), pp. 056-063, 2016. DOI: 10.12983/ijsrk-2016-p0056-0063 DOI: https://doi.org/10.12983/ijsrk-2016-p0056-0063
- B. Aslanbaba, S. Yilmaz, Ö. Tonguç- Yayintaş, D. Özyurt, B.D. Öztürkc, “Total phenol content and antioxidant activity of mosses from yenice forest (ida mountain)”, Journal of Scientific Perspectives, vol. 1(1), pp. 1-12, 2017. DOI: 10.26900/jsp.2017.0 DOI: https://doi.org/10.26900/jsp.2017.0
- M.M. Vujičić, S.M. Milošević, M.S. Sabovljević, A.D. Sabovljević, “Effect of ABA treatment on activities of antioxidative enzymes in selected bryophyte species”, Botanica Serbica, vol. 41(1), pp. 11-15, 2017. DOI: 10.5281/zenodo.452673
- Ö. Tonguç- Yayintaş, O. Sogut, S. Konyalioglu, S. Yilmaz, B. Tepeli, “Antioxidant activities and chemical compositon of different extracts of mosses gathered from turkey”, AgroLife Scientific Journal, vol. 6(2), pp. 205-213, 2017.
- H. Türker, B. Türkyilmaz Ünal, “Potansiyel Antioksidan Kaynağı Olarak Briyofitler”, Anatolian Bryology, vol. 6(2), pp. 129-137, 2020. DOI: 10.26672/anatolianbryology.740094 DOI: https://doi.org/10.26672/anatolianbryology.740094
- I. Kranner, S. Birtic, “A Modulating Role for Antioxidants in Desiccation Tolerance”, Integrative and Comparative Biology, vol. 45, pp. 734-740, 2005. DOI:10.1093/icb/45.5.734 DOI: https://doi.org/10.1093/icb/45.5.734
- M. Nagae, M. Nakata, Y. Takahashi, “Identification of Negative cis-Acting Elements in Response to Copper in the Chloroplastic Iron Superoxide Dismutase Gene of the Moss Barbula unguiculata”, Plant Physiology, vol. 146, pp. 1687-1696, 2008. DOI:10.1104/pp.107.114868 DOI: https://doi.org/10.1104/pp.107.114868
- A. Basile, S. Sorbo, B. Conte, B. Golia, S. Montanari, R. Castaldo- Cobianchi, et al., “Antioxidant activity in extracts from Leptodictyum riparium(Bryophyta), stressed by heavy metals, heat shock, and salinity”, Plant Biosystems - An International Journal Dealing with All Aspects of Plant Biology, vol. 145(1), pp. 77-80, 2011. DOI:10.1080/11263504.2010.509935 DOI: https://doi.org/10.1080/11263504.2010.509935
- D. Gahtori, P. Chaturvedi, “Bryophytes: A Potential Source of Antioxidants. Bryophytes” In: Sabovljević MS, Sabovljević AD, editors. Bryophytes. 1st ed. London: Intechopen, pp. 53-65, 2020. DOI:10.5772/intechopen.84587 DOI: https://doi.org/10.5772/intechopen.84587
- M.F. Abu Bakar, F.A. Karim, M. Suleiman, A. Isha, A. Rahmat, “Phytochemical Constituents, Antioxidant and Antiproliferative Properties of a Liverwort, Lepidozia borneensis Stephani from Mount Kinabalu, Sabah, Malaysia”, Evidence-Based Complementary and Alternative Medicine, pp. 1- 9, 2015. DOI:10.1155/2015/936215 DOI: https://doi.org/10.1155/2015/936215
- S. Mukhia, P. Mandal, D.K. Singh, D. Singh, “Evaluation of anti-diabetic, antioxidant activity and phytochemical constituents of liverworts of Eastern Himalaya”, Journal of Chemical and Pharmaceutical Research, vol. 7(10), pp. 890-900, 2015.
- J. Morantes, C. Prieto, E. Linares, J. Rincón, F. Aristizábal, “Análisis fitoquímico y de actividad biológica del musgo Polytrichum juniperinum”, Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales, vol. 31(121), pp. 473-479, 2007.
- P. Aubad- López, B.A. Rojano, T. Lobo- Echeverri, “Actividad Antioxidante en Musgos”, Scientia et Technica, vol. 33, pp. 23-26, 2007. DOI: https://doi.org/10.22517/23447214.5823
- J.A. Pereañez, T. Lobo-Echeverri, B. Rojano, L. Vargas, M. Fernández, C.A. Gaviria, et al., “Correlation of the inhibitory activity of phospholipase A2 snake venom and the antioxidant activity of Colombian plant extracts”, Brazilian Journal of Pharmacognosy, vol. 20(6), pp. 910-916, 2010. DOI: 10.1590/S0102-695X2010005000030 DOI: https://doi.org/10.1590/S0102-695X2010005000030
- J.C. Rodríguez-Rodríguez, I.J.P. Samudio- Echeverry, L.G. Sequeda- Castañeda, “Evaluation of the Antibacterial Activity of Four Ethanolic Extracts of Bryophytes and Ten Fruit Juices of Commercial Interest in Colombia against Four Pathogenic Bacteria”, Acta Horticulturae, vol. 964, pp. 251-258, 2012. DOI: 10.17660/ActaHortic.2012.964.30 DOI: https://doi.org/10.17660/ActaHortic.2012.964.30
- W. Brand-Williams, M.E. Cuvelier, C. Berset, “Use of a Free Radical Method to Evaluate Antioxidant Activity”, Lebensmittel-Wissenschaft und -Technologie, vol. 28, pp. 25-30, 1995. DOI:10.1016/s0023-6438(95)80008-5 DOI: https://doi.org/10.1016/S0023-6438(95)80008-5
- N.J. Miller, A.T. Diplock, C. Rice- Evans, M.J. Davies, V. Gopinathan, A. Milner, “A Novel Method for Measuring Antioxidant Capacity and its Application to Monitoring the Antioxidant Status in Premature Neonates”, Clinical Science, vol. 84, pp. 407-12, 1993. DOI: 10.1042/cs0840407 DOI: https://doi.org/10.1042/cs0840407
- M.B. Arnao, A. Cano, M. Acosta, “Methods to Measure the Antioxidant Activity in Plant Material. A Comparative Discussion”, Free Radical Research, vol. 31, pp. 89-96, 1999. DOI: 10.1080/10715769900301371 DOI: https://doi.org/10.1080/10715769900301371
- R.L. Prior, X. Wu, K. Schaich, “Standardized Methods for Determination of Antioxidant Capacity and Phenolics in Foods and Dietary Supplements”, Journal of Agricultural and Food Chemistry, vol. 53, pp. 4290-302, 2005. DOI: 10.1021/jf0502698 DOI: https://doi.org/10.1021/jf0502698
- Md. N. Alam, N.J. Bristi, Md. Rafiquzzaman, “Review on in vivo and in vitro methods evaluation of antioxidant activity”, Saudi Pharmaceutical Journal, vol. 21, pp. 143-152, 2012. DOI:10.1016/j.jsps.2012.05.002 DOI: https://doi.org/10.1016/j.jsps.2012.05.002
- R. Re, N. Pellegrini, A. Proteggente, A. Pannala, M. Yang, C. Rice- Evans, “Antioxidant Activity Applying an Improved ABTS Radical Cation Decolorization Assay”, Free Radical Biology and Medicine, vol. 26, pp. 1231-1237, 1999. DOI: https://doi.org/10.1016/S0891-5849(98)00315-3
- D. Villano, M.S. Fernández- Pachón, A.M. Troncoso, M.C. García- Parilla, “The Antioxidant Activity of Wines Determinated ABTS*+ Method: Influence of Simple dilution and Time”, Talanta, vol. 64, pp. 501-509, 2004. DOI: 10.1016/j.talanta.2004.03.021 DOI: https://doi.org/10.1016/j.talanta.2004.03.021
- E.P. Labrinea, C.A. Georgiu, “Stopped-flow Method for Assessment of pH and Timing Effect on the ABTS Total Antioxidant Capacity Assay”, Analytica Chimica Acta, vol. 526(1), pp. 63-68, 2004. DOI:10.1016/j.aca.2004.09.040 DOI: https://doi.org/10.1016/j.aca.2004.09.040
- D. Huang, B. Ou, R.L. Prior, “The Chemistry behind Antioxidant Capacity Assays”, Journal of Agricultural and Food Chemistry, vol. 53, pp. 1841-1856, 2005. DOI:10.1021/jf030723c DOI: https://doi.org/10.1021/jf030723c
- A. Zuleta, M. Esteve, A. Frigola, “ORAC and TEAC assays comparison to measure the antioxidant capacity of food products”, Food Chemestry, vol. 114, pp. 310-316, 2009. DOI:10.1016/j.foodchem.2008.09.033 DOI: https://doi.org/10.1016/j.foodchem.2008.09.033
- S. Beckert, S. Steinhauser, H. Muhle, V. Knoop, “A molecular phylogeny of bryophytes based on nucleotide sequences of the mitochondrial nad5 gene”, Plant Systematics and Evolution, vol. 218, pp. 179-192, 1999. DOI: https://doi.org/10.1007/BF01089226
- K. Renzaglia, S. Schuette, R.J. Duff, R. Ligrone, A.J. Shaw, B.D. Mishler, et al., “Bryophyte phylogeny: Advancing the molecular and morphological frontiers”, The Bryologist, vol. 110(2), pp. 179-213, 2007. DOI: 10.1639/0007-2745(2007)110[179:BPATMA]2.0.CO;2 DOI: https://doi.org/10.1639/0007-2745(2007)110[179:BPATMA]2.0.CO;2
- T.C.H. Cole, H.H. Hilger, B. Goffinet, “Bryophyte Phylogeny Poster (BPP) PeerJ Preprints”, 2019. DOI: 10.7287/peerj.preprints.27571v3/supp-1 DOI: https://doi.org/10.7287/peerj.preprints.27571v1
- S. Vats, A. Alam, “Antioxidant activity of Barbula javanica Doz. et Molk.: A relatively unexplored bryophyte”, Elixir Appl. Botany, vol. 65, pp. 20103-20104, 2013.
- M.M. Makajanma, I. Taufik, A. Faizal, “Antioxidant and antibacterial activity of extract from two species of mosses: Leucobryum aduncum and Campylopus schmidii”, Biodiversitas, vol. 21, pp. 2751-2758, 2020. DOI: 10.13057/biodiv/d210651 DOI: https://doi.org/10.13057/biodiv/d210651
- G.G. Mohandas, M. Kumaraswamy, “Antioxidant Activities of Terpenoids from Thuidium tamariscellum (C. Muell.) Bosch. and Sande-Lac. a Moss”, Pharmacognosy Journal, vol. 10(4), pp. 645- 649, 2018. DOI: 10.5530/pj.2018.4.106 DOI: https://doi.org/10.5530/pj.2018.4.106
- Y. Asakawa, F. Nagashima, T. Hashimoto, M. Toyota, A. Ludwiczuk, I. Komala, T. Ito, Y. Yagi, “Pungent and Bitter, Cytotoxic and Antiviral Terpenoids from Some Bryophytes and Inedible Fungi”, Natural Product Communications, vol. 9 (3), pp. 409 - 417. 2014. DOI:10.1177/1934578x1400900331 DOI: https://doi.org/10.1177/1934578X1400900331
- J.A. López- Saez, “Flavonoides en Bartramiaceae Schwaegr (Musci, Bryophyta): Aspectos quimiosistemáticos y actividad biológica”, (Tesis Doctoral), Universidad Complutense de Madrid. Madrid, 354, pp. 1994.
- J.A. López- Saez, J. Pérez- Alonso, A. Velasco Negueruela, “Contribution to the phylogeny of Philonotis Brid. (Bartramiaceae Schwaegr.): Flavonoids of sections Catenularia (O Mliii.) Par and Euphilonotis Limpr.”, Botanica Complutensis, vol. 21, pp. 51-58. 1996.
- J.A. López- Saez, “A Revision of the Taxonomic Status of Bartramia rosea and B. ruwenzoriensis (Bartramiaceae) Based on Flavonoid Composition” The Brvologist, vol. 99(3), pp. 328-330. 1996. DOI: https://doi.org/10.2307/3244305
- O. Üçüncü, T.B. Cansu, T. Özdemir, Ş. Alpay Karaoğlu, N. Yayli, “Chemical composition and antimicrobial activity of the essential oils of mosses (Tortula muralis Hedw., Homalothecium lutescens (Hedw.) H. Rob., Hypnum cupressiforme Hedw., and Pohlia nutans (Hedw.) Lindb.) from Turkey”, Turkish Journal of Chemistry, vol, 34, pp. 825-834. 2010. DOI:10.3906/kim-1002-62 DOI: https://doi.org/10.3906/kim-1002-62
- K. Sievers, B. Gunther, H. Becker, H.D. Zinsmeeter, “Hypnogenols and other dihydroflavonols from the moss Hypnum cupressiforme*”, Phytochemistry, vol, 31(9), pp. 3233 -3237. 1992. DOI: https://doi.org/10.1016/0031-9422(92)83482-E
- J.A. López- Saez, J. Pérez- Alonso, A. Velasco Negueruela, “Flavonoides en Musgos: consideraciones quimiosistemáticas”, Botanica Complutensis, vol, 21, pp. 9-38. 1996.
- T.M. Lunić, M.M. Oalde, M.R. Mandic, A.D. Sabovljević, M.S. Sabovljević, U.M. Gašić, S.N. Duletić-Laušević, B.Dj. Božić, B. Dj. Božić, B. Dj. Nedeljković, “Extracts Characterization and In Vitro Evaluation of Potential Immunomodulatory Activities of the Moss Hypnum cupressiforme Hedw. Molecules”, vol, 25, pp. 33-43. 2020. DOI:10.3390/molecules25153343 DOI: https://doi.org/10.3390/molecules25153343
- Ö. Tonguç- Yayintaş, D. Alpaslan, Y. Karagul Yuceer, S. Yilmaz, N. Sahiner, “Chemical composition, antimicrobial, antioxidant and anthocyanin activities of mosses (Cinclidotus fontinaloides (Hedw.) P.Beauv. and Palustriella commutata (Hedw.) Ochyra) gathered from Turkey”, Natural Product Research, vol, 31(18), pp. 2169-2173. 2017. DOI: 10.1080/14786419.2016.1277355 DOI: https://doi.org/10.1080/14786419.2016.1277355
- F. Chen, A. Ludwiczuk, G. Wei, X. Chen, B. Crandall- Stotler, J.L. Bowman, “Terpenoid Secondary Metabolites in Bryophytes: Chemical Diversity, Biosynthesis and Biological Functions”, Critical Reviews in Plant Sciences, pp. 1- 22. 2018. DOI: 10.1080/07352689.2018.1482397 DOI: https://doi.org/10.1080/07352689.2018.1482397
- J. Li, L. Wei, C. Chen, D. Liu, Y. Gu, J. Duan-Mu, G. Chen, Y. Song, “Biological metabolites from the bryophyta Hypnum plumaeforme Wilson.”, Chemistry & Biodiversity. DOI:10.1002/cbdv.202000552 DOI: https://doi.org/10.1002/cbdv.202000552
- A. Ludwiczuk, Y. Asakawa, “Terpenoids and Aromatic Compounds from Bryophytes and their Central Nervous System Activity”, Current Organic Chemistry, vol, 24(1), pp. 113-128. 2020. doi:10.2174/1385272824666200120143558 DOI: https://doi.org/10.2174/1385272824666200120143558
- E. Valarezo, V. Vidal, J. Calva, S.P. Jaramillo, J.D. Febres, A. Benitez, “Essential Oil Constituents of Mosses Species from Ecuador”, Journal of Essential Oil Bearing Plants, vol, 21(1), pp. 189–197. 2018. DOI:10.1080/0972060x.2018.1432420 DOI: https://doi.org/10.1080/0972060X.2018.1432420
- M. Commisso, F. Guarino, L. Marchi, A. Muto, A. Piro, F. Degola, “Bryo-Activities: A Review on How Bryophytes Are Contributing to the Arsenal of Natural Bioactive Compounds against Fungi”, Plants, vol, 10, pp. 203-230. 2021. https://doi.org/ 10.3390/plants10020203 DOI: https://doi.org/10.3390/plants10020203
- A. Seyoum, K. Asres, F. Kandeel El-Fiky, “Structure–radical scavenging activity relationships of flavonoids”, Phytochemistry, vol, 67, pp. 2058–2070. 2006. DOI: 10.1016/j.phytochem.2006.07.002 DOI: https://doi.org/10.1016/j.phytochem.2006.07.002
- O. Cartaya, I. Reynaldo, “Flavonoides: Características químicas y aplicaciones”, Cultivos Tropicales, vol. 22 (2), pp. 5-14. 2001.
- S.Q. Sun, M. He, T. Cao, Y. Zhang, W. Han, “Response mechanisms of antioxidants in bryophyte (Hypnum plumaeforme) under the stress of single or combined Pb and/or Ni”, Environmental Monitoring and Assessment, vol, 149, pp. 291-302. 2009. DOI: https://doi.org/10.1007/s10661-008-0203-z
- K. Peters, H. Treutler, S. Döll, A.S.D. Kindt, T. Hankemeier, S. Neumann, “Chemical Diversity and Classification of Secondary Metabolites in Nine Bryophyte Species”, Metabolites. vol. 9(10), pp. 222. 2019. DOI:10.3390/metabo9100222 DOI: https://doi.org/10.3390/metabo9100222
- M.C.F. Proctor, “The physiological basis of bryophyte production”, Botanical Journal of the Linnean Society, vol, 104, pp. 61-77. 1990. DOI: https://doi.org/10.1111/j.1095-8339.1990.tb02211.x
- X. Zhang, Y. Zhao, S. Wang, “Responses of antioxidant defense system of epilithic mosses to drought stress in karst rock desertified areas”, Acta Geochimica, vol, 36(2), pp. 205–212. 2017. DOI 10.1007/s11631-017-0140-z DOI: https://doi.org/10.1007/s11631-017-0140-z
- A. Baxter, R. Mittler, N. Suzuki, “ROS as key players in plant stress signaling”, Journal of Experimental Botany, vol, 65(5), pp. 1229–1240. 2013. DOI:10.1093/jxb/ert375 DOI: https://doi.org/10.1093/jxb/ert375
- W.E. Seel, G.A.F. Hendry, J.A. Lee, “Effects of Desiccation on some Activated Oxygen Processing Enzymes and Anti-Oxidants in Mosses”, Journal of Experimental Botany, vol, 43(253), pp. 1031-1037. 1992. DOI: https://doi.org/10.1093/jxb/43.8.1031
- X. Wang, J. Cao, X. Dai, J. Xiao, Y. Wu, Q. Wang, “Total flavonoid concentrations of bryophytes from Tianmu Mountain, Zhejiang Province (China): Phylogeny and ecological factors”, PLoS ONE, vol. 12(3), pp. 1-10, 2017. DOI:10.1371/journal. pone.0173003 DOI: https://doi.org/10.1371/journal.pone.0173003