Ir al menú de navegación principal Ir al contenido principal Ir al pie de página del sitio

Seroprevalencia de Mycobacterium avium subsp. paratuberculosis en pequeños rumiantes de un aprisco de Antioquia, Colombia

Resumen

La paratuberculosis es una enfermedad infecciosa crónica causada por Mycobacterium avium subsp. paratuberculosis (MAP). El objetivo de este estudio fue determinar la seroprevalencia de MAP y la asociación existente entre el estatus serológico a MAP y factores individuales en cabras y ovejas de un aprisco en Antioquia, Colombia. Se estudiaron 53 caprinos y 6 ovinos mayores a dos años de edad, de los cuales se tomó información sobre factores individuales y una muestra de sangre para obtener suero sanguíneo. La presencia de anticuerpos contra MAP se determinó por medio de una prueba de ELISA, mientras que la información se analizó descriptivamente. La prueba de ELISA no detectó ningún animal positivo o sospechoso entre los 59 analizados, por lo que no se pudo establecer asociación entre el estatus serológico a MAP y factores individuales. Este es el primer estudio que reporta la búsqueda de anticuerpos contra MAP en una población caprina, y el cuarto en una población ovina en Colombia. Diversos factores pueden explicar el estatus serológico de los animales muestreados. Es necesario continuar con estudios similares en otros apriscos de la región y del país para determinar el estatus real de la infección en pequeños rumiantes en Colombia.

Palabras clave

enfermedad de Johne, paratuberculosis, pequeños rumiantes, perdida de peso

PDF

Citas

  1. Chiodini R. Abolish Mycobacterium paratuberculosis strain 18. Clin Microbiol Rev. 1993; 31: 1958-1986. DOI: https://doi.org/10.1128/jcm.31.7.1956-1958.1993
  2. Kruze J., Salgado M., Collins M. Paratuberculosis en rebaños caprinos chilenos. Arch. Med. Vet. 2007; 39: 147-152. DOI: http://doi.org/10.4067/S0301-732X2007000200008. DOI: https://doi.org/10.4067/S0301-732X2007000200008
  3. Clarke CJ. The pathology and pathogenesis of paratuberculosis in ruminants and other species. J. Comp. Pathol. 1997; 116: 217-261. DOI: http://doi.org/10.1016/S0021-9975(97)80001-1. DOI: https://doi.org/10.1016/S0021-9975(97)80001-1
  4. Begg D., Whittington R. Paratuberculosis in Sheep. En: Behr MA., Collins DM. Paratuberculosis Organism, Disease, Control. 1ra ed. Oxfordshire, UK: CAB International. 2010: 157-168. DOI: http://doi.org/10.1079/9781845936136.0157. DOI: https://doi.org/10.1079/9781845936136.0157
  5. Robbe-Austerman S. Control of paratuberculosis in small ruminants. Vet. Clin. North Am. Food Anim. Pract. 2011; 27: 609-620. DOI: http://doi.org/10.1016/j.cvfa.2011.07.007. DOI: https://doi.org/10.1016/j.cvfa.2011.07.007
  6. Clarke CJ., Little D. The pathology of ovine paratuberculosis: gross and histological changes in the intestine and other tissues. J. Comp. Pathol. 1996; 114: 419-437. DOI: http://doi.org/10.1016/S0021-9975(96)80017-X. DOI: https://doi.org/10.1016/S0021-9975(96)80017-X
  7. Juste RA., Perez V. Control of Paratuberculosis in Sheep and Goats. Vet. Clin. North Am. Food Anim. Pract. 2011; 27: 127-138. DOI: http://doi.org/10.1016/j.cvfa.2010.10.020. DOI: https://doi.org/10.1016/j.cvfa.2010.10.020
  8. Anonymous. The economic impact of OJD infection on sheep farms. Meat and Livestock Australia. 2005. Disponible en: http://www.animalhealthaustraliacom.au/wp-content/uploads/2011/04/The-economic-impact-of-OJD.pdf.
  9. Djønne B. Paratuberculosis in Goats. En: Behr MA, Collins DM, editores. Paratuberculosis Organism, Disease, Control. 1ra ed. Oxfordshire, UK: CAB International; 2010:169-178. DOI: http://doi.org/10.1079/9781845936136.0169. DOI: https://doi.org/10.1079/9781845936136.0169
  10. Storset AK., Hasvold HJ., Valheim M., Brun-Hansen H., Berntsen G. Subclinical paratuberculosis in goats following experimental infection. An immunological and microbiological study. Vet. Immunol. Immunopathol. 2001; 80: 271–287. DOI: http://doi.org/10.1016/S0165-2427(01)00294-X. DOI: https://doi.org/10.1016/S0165-2427(01)00294-X
  11. Kostoulas P., Leontides L., Billinis C. The association of sub-clinical paratuberculosis with the fertility of greek dairy ewes and goats varies whit parity. Prev Vet Med. 2006; 74: 226-238. DOI: http://doi.org/10.1016/j.prevetmed.2005.12.001. DOI: https://doi.org/10.1016/j.prevetmed.2005.12.001
  12. Angelidou E., Kostoulas P., Leontides L. Flock-level factors associated with the risk of Mycobacterium avium subsp. paratuberculosis (MAP) infection in Greek dairy goat flocks. Prev Vet Med. 2014; 117: 233-41. DOI: http://doi.org/10.1016/j.prevetmed.2014.09.002. DOI: https://doi.org/10.1016/j.prevetmed.2014.09.002
  13. Stewart D., Vaughan J., Stiles P. A long-term bacteriological and immunological study in Holstein- Friesian cattle experimentally infected with Mycobacterium avium subsp. Paratuberculosis and necropsy culture results for Holstein- Friesian cattle, merino sheep and angora goats. Vet. Microbiol. 2007; 122: 83-96. DOI: http://doi.org/10.1016/j.vetmic.2006.12.030. DOI: https://doi.org/10.1016/j.vetmic.2006.12.030
  14. Castellanos MJ., Rodríguez CJ., Toro CW. Agenda de investigación y desarrollo tecnológico para la cadena cárnica ovino caprina en Colombia. MADR-Tecnos. 2010.
  15. De Juan L., Mateos A., Domínguez L., Sharp J., Stevenson K. Genetic diversity of Mycobacterium avium subspecies paratuberculosis isolates from goats detected by pulsed-field gel electrophoresis. Veterinary Microbiology. 2005: 106: 249-257. DOI: http://doi.org/10.1016/j.vetmic.2004.12.013. DOI: https://doi.org/10.1016/j.vetmic.2004.12.013
  16. Over K., Crandall P., O’Bryan C., Ricke C. Current perspectiveson Mycobacterium avium subsp. paratuberculosis Johne’s disease, and Crohn’s disease: a review. Crit. Rev. Microbiol. 2011; 37:141-156. DOI: http://doi.org/10.3109/1040841X.2010.532480. DOI: https://doi.org/10.3109/1040841X.2010.532480
  17. Sechi L., Mura M., Tanda F., Lissia A., Solinas A, et. al. Identification of Mycobacterium avium subsp. paratuberculosis in biopsy specimens from patients with Crohn’s disease identified by in situ hybridization. J. Clin. Microbiol. 2001; 39: 4514-4517. DOI: http://doi.org/10.1128/JCM.39.12.4514-4517.2001. DOI: https://doi.org/10.1128/JCM.39.12.4514-4517.2001
  18. Mancipe L., Sánchez J., Rodríguez G. Estudio de la paratuberculosis en un rebaño de ovinos de la sabana de Bogotá mediante la utilización de tres técnicas diagnósticas. Rev. Med. Vet. 2009; 18: 33-51.
  19. Mogollón G., De Galvis A., Tovar L., Murillo N., Mosses N. Prevalencia de paratuberculosis ovina en el altiplano cundiboyacense. Revista ICA. 1983; 18: 479-484
  20. Murillo-Rondón LE. Prevalencia serológica de la paratuberculosis ovina por la prueba de fijación de complemento. Tesis de pregrado, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional de Colombia, Bogotá. 1981.
  21. Fernández-Silva JA., Correa-Valencia NM., Ramírez-Vásquez N. Systematic review of the prevalence of paratuberculosis in cattle, sheep, and goats in Latin America and the Caribbean. Trop Anim Health Prod. 2014; 46(8): 1321-40. DOI: http://doi.org/10.1007/s11250-014-0656-8. DOI: https://doi.org/10.1007/s11250-014-0656-8
  22. Fernández-Silva JA., Abdulmawjood A., Akineden O., Bulte M. Serological and molecular detection of Mycobacterium avium subsp. paratuberculosis in cattle of dairy herds in Colombia. Trop Anim Health Prod. 2011; 43: 1501-1507. DOI: http://doi.org/10.1007/s11250-011-9833-1. DOI: https://doi.org/10.1007/s11250-011-9833-1
  23. Fernández-Silva JA., Abdulmawjood A., Bulte M. Diagnosis and Molecular Characterization of Mycobacterium avium subsp. paratuberculosis from dairy cows in Colombia. Vet Med Int. 2011; 1: 29. DOI: https://doi.org/10.4061/2011/352561
  24. Ramírez-Vásquez N., Rodríguez B., Fernández-Silva JA. Diagnóstico clínico e histopatológico de paratuberculosis bovina en un hato lechero en Colombia. MVZ. 2001; 16(3): 2742-2753. DOI: https://doi.org/10.21897/rmvz.275
  25. Ramírez-García R., Maldonado-Estrada JG. Detection of macrophages infected with Mycobacterium avium subspecies paratuberculosis in a cow with clinical stage IV of the disease. A case report. Rev Colomb Cienc Pecu. 2013; 26: 219-225.
  26. Zapata MM., Arroyave O., Ramírez R., Piedrahita C., Rodas JD. Identification of Mycobacterium avium subspecies paratuberculosis by PCR techniques and establishment of control programs for bovine paratuberculosis in dairy herds. Rev Colomb Cienc Pecu. 2010; 23: 17-27.
  27. Fry MP., Kruze J., Collins MT. Evaluation of four commercial enzyme-linked immunosorbent assays for the diagnosis of bovine paratuberculosis in Chilean dairy herds. J Vet Diagn Investig. 2008;20(3): 329-32. DOI: http://doi.org/10.1177/104063870802000311. DOI: https://doi.org/10.1177/104063870802000311
  28. Clark DL., Koziczkowski JJ., Radcliff RP., Carlson RA., Ellingson JL. Detection of Mycobacterium avium subspecies paratuberculosis: comparing fecal culture versus serum enzyme-linked immunosorbent assay and direct fecal polymerase chain reaction. Journal of Dairy Science. 2008;91: 2620-2627. DOI: http://doi.org/10.3168/jds.2007-0902. DOI: https://doi.org/10.3168/jds.2007-0902
  29. Nielsen SS., Toft N. Ante-mortem diagnosis of paratuberculosis: a review of accuracies of ELISA, interferon-gamma assay and faecal culture techniques. Vet Microbiol. 2008; 2129:217-235. DOI: http://doi.org/10.1016/j.vetmic.2007.12.011. DOI: https://doi.org/10.1016/j.vetmic.2007.12.011
  30. Stevenson K. Diagnosis of Johne´s disease: current limitations and prospects. Cattle Practice. 2010b; 18: 104-109.
  31. Bauman CA., Jones-Bitton A., Jansen J., Kelton D., Menzies P. Evaluation of fecal culture and fecal RT-PCR to detect Mycobacterium avium ssp. paratuberculosis fecal shedding in dairy goats and dairy sheep using latent class Bayesian modeling. BMC veterinary Research. 2016; 12: 212. DOI: http://doi.org/10.1186/s12917-016-0814-5. DOI: https://doi.org/10.1186/s12917-016-0814-5
  32. Nielsen SS., Toft N. A review of prevalence of paratuberculosis in flocked animals in Europe. Preventive Veterinary Medicine. 2009; 88:1-14. DOI: http://doi.org/10.1016/j.prevetmed.2008.07.003. DOI: https://doi.org/10.1016/j.prevetmed.2008.07.003
  33. Nielsen SS. Immune-based Diagnosis of Paratuberculosis. In: Behr, M.A., Collins, D.M. (Eds.), Paratuberculosis: Organism, Disease, Control. CAB International, Oxfordshire. 2010; 284-293. DOI: http://doi.org/10.1079/9781845936136.0284. DOI: https://doi.org/10.1079/9781845936136.0284
  34. Collins MT., Gardner IA., Garry FB., Roussel AJ., Wells SJ. Consensus recommendations on diagnostic testing for the detection of paratuberculosis in cattle in the United States. J. Am. Vet. Med Assoc. 2006; 229: 1912-1919. DOI: http://doi.org/10.2460/javma.229.12.1912. DOI: https://doi.org/10.2460/javma.229.12.1912
  35. Collins DM., Hilbink F., West DM. Investigation of Mycobacterium paratuberculosis in sheep by faecal culture, DNA characterization and the polymerase chain reaction. Vet Rec. 1993; 133(24): 599.
  36. De Lisle GW., Collins DM., Huchzermeyer HF. Characterization of ovine strains of Mycobacterium paratuberculosis by restriction endonuclease analysis and DNA hybridization. Onderstepoort J Vet Res. 1992; 59(2): 163.
  37. Shulaw WP., Bech-Nielsen S., Rings DM., Getzy DM., Woodruff TS. Serodiagnosis of paratuberculosis in sheep by use of agar gel immunodiffusion. Am J Vet Res. 1993; 54: 13-19.
  38. Cocito CP., Coene M., De Kesel M., Poupart P., Vannuffel P. Paratuberculosis. Clin Microbiol Rev. 1994; 7: 328-345. DOI: http://doi.org/10.1128/CMR.7.3.328. DOI: https://doi.org/10.1128/CMR.7.3.328
  39. Collins MT. Diagnosis of paratuberculosis. Vet Clin North Am. Food Anim Pract. 1996; 12: 357-371. DOI: http://doi.org/10.1016/S0749-0720(15)30411-4. DOI: https://doi.org/10.1016/S0749-0720(15)30411-4
  40. Burnside DM., Rowley BO. Evaluation of an enzyme-linked immunosorbent assay for diagnosis of paratuberculosis in goats. Am J Vet Res. 1994; 55: 465-466.
  41. Dubash K., Shulaw WP., Bech-Nielsen S., Stills HF., Slemons RD. Evaluation of an agar gel immunodiffusion test kit for detection of antibodies to Mycobacterium paratuberculosis in sheep. J Am Vet Med Assoc. 1996; 208: 401-403
  42. Nielsen SS., Nielsen KK., Huda A., Condron R., Collins MT. Diagnostic techniques for paratuberculosis. In: Bulletin of the international dairy federation. IDF. 2001; 362: 5-17.
  43. Ahmed IM. Serodiagnosis of Johne's disease by indirect ELISA in ovine. Iraqi Journal of Veterinary Sciences. 2010; 24: 41-43. DOI: https://doi.org/10.33899/ijvs.2010.5576
  44. Sergeant E., Marshall D., Eamens J., Kearns C., Whittington RJ. Evaluation of an absorbed ELISA and an agar-gel immuno-diffusion test for ovine paratuberculosis in sheep in Australia. Prev. Vet. Med. 2003; 61: 235-248. DOI: http://doi.org/10.1016/j.prevetmed.2003.08.010. DOI: https://doi.org/10.1016/j.prevetmed.2003.08.010
  45. Holstad G., Sigurðardóttir Ó., Storset A., Tharaldsen J., Nyberg O., Schönheit J., Djønne B. Description of the infection status in a Norwegian cattle herd naturally infected by Mycobacterium avium subsp. paratuberculosis. Acta Vet. Scand. 2005; 46: 45-56. DOI: http://doi.org/10.1186/1751-0147-46-45. DOI: https://doi.org/10.1186/1751-0147-46-45
  46. Hemalatha S., Parimal R., Purushothaman V., Iyue M. Paratuberculosis in different breeds of sheep: A retrospective study of cases. Int J Mycobacteriol. 2013; 2: 166-170. DOI: http://doi.org/10.1016/j.ijmyco.2013.07.002. DOI: https://doi.org/10.1016/j.ijmyco.2013.07.002
  47. Morris CA., Hickey SM., Henderson HV. The effect of Johne’s disease on production traits in Romney, Merino and Merino × Romney-cross ewes. N Z Vet J. 2006; 54: 204-209. DOI: http://doi.org/10.1080/00480169.2006.36698. DOI: https://doi.org/10.1080/00480169.2006.36698
  48. Tripathi BW., Paritra NS. Status of paratuberculosis in goats – a 5 years study based on postmortem cases. Indian J. Vet. Pathol. 1999; 23:79-80.
  49. Jakobsen MB., Alban L., Nielsen SS. A cross-sectional study of paratuberculosis in 1155 Danish dairy cows. Prev. Vet. Med. 2005; 46: 15-27. DOI: http://doi.org/10.1016/S0167-5877(00)00138-0. DOI: https://doi.org/10.1016/S0167-5877(00)00138-0
  50. Radostits OM., Gay CC., Hinchcliff KW., Constable PD. Diseases associated with bacteria. En: Rodenhuis J, Ball E, editores. Veterinary Medicine: a Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats, 10 ed. USA: Saunders: Elsevier; 2007. p. 1017-1044.
  51. Mainar-Jaime R., Vázquez-Boland J. Factors associated with seroprevalence to Mycobacterium paratuberculosis in small-ruminant farms in the Madrid region (Spain). Prev. Vet. Med. 1998; 34: 317-327. DOI: http://doi.org/10.1016/S0167-5877(97)00091-3. DOI: https://doi.org/10.1016/S0167-5877(97)00091-3

Descargas

Los datos de descargas todavía no están disponibles.

Artículos similares

También puede {advancedSearchLink} para este artículo.