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Vol. 11 No. 2 (2020)
Vol 11, Núm.2 (2020): Julio-Diciembre

Artículos de investigación / Research papers

Cellular and genetic damage as determinants of pesticide toxicity

https://doi.org/10.19053/01217488.v11.n2.2020.11245

Published 2020-06-19

  • Duvan Sebastián Valbuena
    • ,
  • María Paula Meléndez-Flórez
    • ,
  • Victoria Eugenia Villegas
    • ,
  • Magda Carolina Sánchez
    • ,
  • Milena Rondón-Lagos

Duvan Sebastián Valbuena
Universidad Pedagogica y Tecnologica de Colombia

María Paula Meléndez-Flórez
Universidad Pedagogica y Tecnologica de Colombia

Victoria Eugenia Villegas
Universidad del Rosario

Magda Carolina Sánchez
Universidad del Rosario

Milena Rondón-Lagos
Universidad Pedagogica y Tecnológica de Colombia

Abstract

The use of pesticides in Colombia has allowed effective pest control, increasing agricultural, forestry and livestock productivity. However, both occupational and environmental exposure to pesticides can generate harmful effects on human health, since they can induce damage to genetic material, causing the development of diseases, including cancer. Although the harmful effects caused by exposure to pesticides are widely known, specific information about genomic damage (gene and chromosomal damage) generated by exposure to them is scarce or absent. This review aims to describe the cellular and genetic effects induced by exposure to pesticides, as well as their implications for disease development. Considering the wide use of pesticides in

the world, as well as their impacts on health, increasing our knowledge of their harmful effects will allow us to establish future possibilities for applying tests for the early detection of diseases, as well as developing programs and/or preventive actions aimed at protecting the most vulnerable individuals in occupational and environmental settings.

Keywords

Chromosomal Instability, Genotoxicity, Occupational exposure, Pesticides

PDF (Español)

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