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Vol. 11 No. 2 (2020)
Vol 11, Núm.2 (2020): Julio-Diciembre

Artículos de investigación / Research papers

Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin.

https://doi.org/10.19053/01217488.v11.n2.2020.10864

Published 2020-06-04

  • Jadileyg Gabriela León Pérez
    • ,
  • Gethzemani Mayeli Estrada Villegas
    • ,
  • Juan Morales-Corona
    • ,
  • Roberto Olayo-Gonzalez
    • ,
  • Roberto Olayo-Valles

Jadileyg Gabriela León Pérez
Universidad Pedagógica y Tecnológica de Colombia

Gethzemani Mayeli Estrada Villegas
CONACYT-Centro de Investigación en Química Aplicada-México.

Juan Morales-Corona
Universidad Autónoma Metropolitana-México

Roberto Olayo-Gonzalez
Universidad Autónoma Metropolitana-México

Roberto Olayo-Valles
Universidad Autónoma Metropolitana-México

Abstract

To dose curcumin (Cur) while avoiding its degradation, a polymeric material consisting of fibers with core/shell structure was designed. Coaxial electrospinning allowed us to obtain fibers with poly(lactic acid) (PLA) core, and carboxymethylcellulose (CMC) shell. CMC/PLA fibers were compared with conventional PLA fibers. Scanning electron microscopy images allowed us to characterize the core/shell structure of CMC/PLA-Cur fibers. The presence of Cur in the fibers was confirmed by Raman spectroscopy. Thermogravimetric analysis and differential scanning calorimetry showed the effect of Cur on the thermal behavior of the fibers, and showed contrasting behavior between CMC/PLA and PLA fibers. Cur release experiments were performed at physiological pH and the results were fitted with the Korsmeyer-Peppas model. The release rate of CMC/PLA fibers was significantly lower than that of PLA fibers.

Keywords

Carboxymethylcellulose, Poly (lactic acid), Curcumin, Core/Shell Fibers, Coaxial Electro-spinning.

PDF (Español)

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