Epidemiological, Clinical and Diagnostic Features of FeLV and FIV: An Updated Review





cats, diagnosis, feline immunodeficiency virus, feline leukemia virus, prevalence


Feline leukemia (FeLV) and immunodeficiency (FIV) viruses are pathogens which affect domestic cats and are classified within the Retroviridae family. These feline retroviruses feature a high capacity of mutation and recombination, which derives in a broad population of viral subtypes with variable pathogenic capacity. These viruses are of great importance in feline health, not only because of the severity of the clinical signs in patients, but also due to the diagnostic complexity which they can pose. The range of prevalence is wide among different studies and geographical zones, probably due to the influence of risk factors, clinical condition of cats and diagnostic tests used. The clinical signs of FeLV disease are variable, depending on the viral subtype and the host’s immune-compromise, as there could be lymphoma, leukemia, red cell aplasia myelosuppresion and immunodeficiency. On another hand, FIV has a marked tropism towards TCD4+ lymphocytes, triggering a characteristic immunodeficiency, but a frequent neurotropism has also been described. In both viruses, serological diagnostic is a routine procedure; however, in some situations it is not possible to identify correctly the infected cats. Recent studies have included Polymerase Chain Reaction (PCR) as a diagnostic method, opening a possibility to decreasing diagnostic errors for FeLV, but its effectiveness for FIV detection is still being discussed. The purpose of the present article is to provide updated and precise information about epidemiological, clinical and diagnostic aspects of FeLV and FIV in domestic cats.


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Aiyaranoi, K., Boonchalaew, N., Chawnan, N., Chotikul, S., & Kampa, J. (2018). Prevalence of Feline Immunodeficiency Virus & Feline Leukemia Virus in Clinically Healthy Cats in Khon Kaen Province. Thai Journal of Veterinary Medicine, 48(1), 117-121.

Anai, Y., Ochi, H., Watanabe, S., Nakagawa, S., Kawamura, M., Gojobori, T., & Nishigaki, K. (2012). Infectious Endogenous Retroviruses in Cats and Emergence of Recombinant Viruses. Journal of Virology, 86(16), 8634-8644. https://doi.org/10.1128/JVI.00280-12.

Azócar-Aedo, L., & Monti, G. (2018). Risk Factors for Seropositivity to Feline Retroviruses among Owned Domestic Cats in Valdivia, Southern Chile. Current Science, 114(7), 1548-1553. https://doi.org/10.18520/cs/v114/i07/1548-1553.

Beatty, J. (2017). Feline Immunodeficiency Virus Infection. In S. J. Ettinger, E.C. Feldman & E. Coté (Eeds.). Textbook of Veterinary Internal Medicine (8th ed.) (pp. 2422-2423). St. Louis, Missouri: Elsevier.

Burling, A. N., Levy, J. K., Scott, H. M., Crandall, M. M., Tucker, S. J., Wood, E. G., & Foster, J. D. (2017). Seroprevalences of Feline Leukemia Virus and Feline Immunodeficiency Virus Infection in Cats in the United States and Canada and Risk Factors for Seropositivity. Journal of the American Veterinary Medical Association, 251(2), 187-194. https://doi.org/10.2460/javma.251.2.187.

Chiu, E. S., Hoover, E. A., & VandeWoude, S. (2018). A Retrospective Examination of Feline Leukemia Subgroup Characterization: Viral Interference Assays to Deep Sequencing. Viruses, 10(1), 29. https://doi.org/10.3390/v10010029.

Da-Costa, F. V. A., Del-Valle, S., Machado, G., Corbellini, L. G., Coelho, E. M., Rosa, R. B., & González, F. H. D. (2017). Hematological Findings and Factors Associated with Feline Leukemia Virus (FeLV) and Feline Immunodeficiency Virus (FIV) Positivity in Cats from Southern Brazil. Pesquisa Veterinária Brasileira, 37(12), 1531-1536. https://doi.org/10.1590/S0100-736X2017001200028.

Eckstrand, C. D., Hillman, C., Smith, A. L., Sparger, E. E., & Murphy, B. G. (2016). Viral Reservoirs in Lymph Nodes of FIV-Infected Progressor and Long-Term Non-Progressor Cats during the Asymptomatic Phase. PLoS ONE, 11(1), e0146285. https://doi.org/10.1371/journal.pone.0146285.

Eckstrand, C. D., Sparger. E. E., & Murphy, B. G. (2017). Central and Peripheral Reservoirs of Feline Immunodeficiency Virus in Cats: A Review. Journal of General Virology, 98(8), 1985-1996. https://doi.org/10.1099/jgv.0.0008660008661985.

Filoni, C., Helfer-Hungerbuehler. A. K., Catão-Dias, J. L., Marques, M. C., Neves, T. L., Reinacher M., & Hofmann-Lehmann, R. (2017). Putative Progressive and Abortive Feline Leukemia Virus Infection Outcomes in Captive Jaguarundis (Puma yagouaroundi). Virology Journal, 14, 226. https://doi.org/10.1186/s12985-017-0889-z.

Galdo-Novo, S., Bucafusco, D., Díaz, L. M., & Bratanich. A. C. (2016). Viral Diagnostic Criteria for Feline Immunodeficiency Virus and Feline Leukemia Virus Infections in Domestic Cats from Buenos Aires, Argentina. Revista Argentina de Microbiología, 48(4), 293-297. https://doi.org/10.1016/j.ram.2016.07.003.

González S. A., & Affranchino, J. L. (2018). Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding. Viruses, 10(5), 261. https://doi.org/10.3390/v10050261.

Hall, E. J., & Day M. J. (2017). Diseases of the Small Intestine. In S.J. Ettinger, E.C. Feldman & E. Coté (eds.). Textbook of Veterinary Internal Medicine (8th ed.) (pp. 3643-3820). St. Louis, Missouri: Elsevier.

Hartmann, K. (2017). Regressive and Progressive Feline Leukemia Virus Infections – Clinical Relevance and Implications for Prevention and Treatment. Thai Journal of Veterinary Medicine Supplement, 47, S109-S112.

Hartmann, K., & Levy, J. K. (2017). Feline Leukemia Virus infection. In S.J. Ettinger, E.C. Feldman & E. Coté (eds.). Textbook of Veterinary Internal Medicine (8th ed.) (pp. 2442-2455). St. Louis, Missouri: Elsevier.

Hwang, J., Gottdenker, N. L., Oh, D. H., Nam, H. W., Lee, H., & Chun, M. S. (2018). Disentangling the Link between Supplemental Feeding, Population Density, and the Prevalence of Pathogens in Urban Stray Cats. PeerJ, 6, e4988. https://doi.org/10.7717/peerj.4988.

Johns, J. L. (2017). Immune-Mediated and Other Nonneoplastic White Blood Cell Disorders. In S.J. Ettinger, E.C. Feldman & E. Coté (eds.). Textbook of Veterinary Internal Medicine (8th ed.) (pp. 2137-2150). St. Louis, Missouri: Elsevier.

Kawasaki, J., & Nishigaki, K. (2018). Tracking the Continuous Evolutionary Processes of an Endogenous Retrovirus of the Domestic Cat: ERV-DC. Viruses, 10(4), 179. https://doi.org/10.3390/v10040179.

Kennedy, M., & Little, S. E. (2012). Viral Diseases. Chapter 33 Infectious Diseases. In S.E. Little (ed.). The Cat Clinical Medicine and Management (pp. 1029-1070). St. Louis, Missouri: Elsevier Saunders.

Krecic, M. R., Velineni, S., Meeus, P., Fan, H., & Loenser, M. (2018). Diagnostic Performances of two Rapid Tests for Detection of Feline Leukemia Virus Antigen in Sera of Experimentally Feline Leukemia Virus-Infected Cats. Journal of Feline Medicine and Surgery Open Reports, 4(1), 2055116917748117. https://doi.org/10.1177/2055116917748117.

Lacerda, L. C., Silva, A. N., Freitas, J. S., Cruz, R. D. S., Said, R. A., & Munhoz, A. D. (2017). Feline Immunodeficiency Virus and Feline Leukemia Virus: Frequency and Associated Factors in Cats in Northeastern Brazil. Genetics and Molecular Research, 16(2), gmr16029633. https://doi.org/10.4238/gmr16029633.

Lascelles, B. D. X., & White, R. A. S. (2016). Tumours of the Small Intestines. In J.M. Dobson & B.D.X. Lascelles (eds.). BSAVA Manual of Canine and Feline Oncology (third ed.) (pp. 212-215) India: BSAVA Parksons Graphics. https://doi.org/10.22233/9781905319749.15.5.

MacLachlan, N. J., & Dubovi, E. J. (2017). Fenner´s Veterinary Virology (5th ed.) (pp. 269-297). Cambridge, USA: Academic Press Elsevier.

Mandara, M. T., Motta, L., & Calò, P. (2016). Distribution of Feline Lymphoma in the Central and Peripheral Nervous Systems. The Veterinary Journal, 216, 109-116. https://doi.org/10.1016/j.tvjl.2016.07.013.

Marcondes, M., Hirata, K. Y., Vides, J. P., Sobrinho, L. S. V., Azevedo, J. S., Vieira, T. S. W. J., & Vieira, R. (2018). Infection by Mycoplasma spp., Feline Immunodeficiency Virus and Feline Leukemia Virus in Cats from an Area Endemic for Visceral Leishmaniasis. Parasites & Vectors, 11, 131. https://doi.org/10.1186/s13071-018-2716-9.

Meeker, R. B., & Hudson, L. (2017). Feline Immunodeficiency Virus Neuropathogenesis: A Model for HIV-Induced CNS Inflammation and Neurodegeneration. Veterinary Sciences, 4(1), 14. https://doi.org/10.3390/vetsci4010014.

Menéndez-Arias, L., Sebastián-Martín, A., & Álvarez, M. (2017). Viral Reverse Transcriptases. Virus Research, 234, 153-176. https://doi.org/10.1016/j.virusres.2016.12.019.

Nesina, S., Helfer-Hungerbuehler, A. K., Riond, B., Boretti, F. S., Willi, B., Meli, M. L., Grest, P., & Hofmann-Lehmann, R. (2015). Retroviral DNA- The Silent Winner: Blood Transfusion Containing Latent Feline Leukemia Provirus Causes Infection and Disease in Naïve Recipient Cats. Retrovirology, 12, 105. https://doi.org/10.1186/s12977-015-0231-z.

Palmero, C. M. L., & Carballés. P. V. (2012). Enfermedades infecciosas felinas. Zaragoza, España: Servet.

Pan, M. Q., Wang, J. C., & Wang, Y. J. (2018). The Prevalence and Genetic Diversity of Feline Immunodeficiency Virus and Feline Leukemia Virus among Stray Cats in Harbin, China. Turkish Journal of Zoology, 42, 245-251. https://doi.org/10.3906/zoo-1706-3.

Paulin, M. V., Couronné, L., Beguin, J., Le Poder, S., Delverdier, M., Sermin, M. O., Bruneau, J., Cerf-Bensussan, N., Malamut, G., Cellier, C., Benchekroun, G., Tiret, L., German, A. J., Hermine, O., & Freiche, V. (2018). Feline Low-Grade Alimentary Lymphoma: An Emerging Entity and A Potential Animal Model for Human Disease. BMC Veterinary Research, 14(1), 306. https://doi.org/10.1186/s12917-018-1635-5.

Perharić, M., Starešina, V., Turk, N., Barbić, L., Štritof, Z., Hađina, S., Habuš, J., Stevanović, V., Martinković, K., Perko, V. M., & Milas, Z. (2018). The Epidemiology Features of Retroviral Infections in Domestic Cats from the Zagreb Urban Area. Veterinarski Archiv, 88(3), 345-354. https://doi.org/10.24099/vet.arhiv.170406b.

Power. C. (2018). Neurologic Disease in Feline Immunodeficiency Virus Infection: Disease Mechanisms and Therapeutic Interventions for NeuroAIDS. Journal of Neurovirology, 24(2), 220-228. https://doi.org/10.1007/s13365-017-0593-1.

Powers, J. A., Chiu, E. S., Kraberger, S. J., Roelke-Parker, M., Lowery, I., Erbeck, K., Troyer, R., Carver, S., & VandeWoude, S. (2018). Feline Leukemia Virus (FeLV) Disease Outcomes in a Domestic Cat Breeding Colony: Relationship to Endogenous FeLV and Other Chronic Viral Infections. Journal of Virology, 92(18), e00649-18. https://doi.org/10.1128/JVI.00649-18.

Radford, A., & Dawson, S. (2016). Diagnosis of Viral Infections. In J.M. Dobson & B. D. X. Lascelles (eds.). BSAVA Manual of Canine and Feline Oncology (third ed.) (pp. 533-548). India: BSAVA Parksons Graphics. https://doi.org/10.22233/9781910443255.28.

Ramírez, H., Autran, M., García, M. M., Carmona, M. A., Rodríguez, C., & Martínez, H. A. (2016). Genotyping of Feline Leukemia Virus in Mexican Housecats. Archives of Virology, 161(4), 1039-1045. https://doi.org/10.1007/s00705-015-2740-4.

Sarvani, E., Tasker, S., Kova´cević, F. M., Francuski, A. J., Andric, N., Anquino, L., English, S., Attipa, C., Leutenegger, C. M., Helps, C. R., & Papasouliotis, K. (2018). Prevalence and Risk Factor Analysis for Feline Haemoplasmas in Cats from Northern Serbia, with Molecular Subtyping of Feline Immunodeficiency Virus. Journal of Feline Medicine and Surgery, 4(1), 1-10. https://doi.org/10.1177/2055116918770037.

Sivagurunathan, A., Atwa, A. M., & Lobetti R. (2018). Prevalence of Feline Immunodeficiency Virus and Feline Leukaemia Virus Infection in Malaysia: A Retrospective Study. Journal of Feline Medicine and Surgery, 4(1), 1-5. https://doi.org/10.1177/2055116917752587.

Stavisky, J., Dean, R. S., & Molloy, M. H. (2017). Prevalence of and Risk Factors for FIV and FeLV Infection in Two Shelters in the United Kingdom (2011-2012). Veterinary Record, 181(17), 451. https://doi.org/10.1136/vr.103857.

Southard, T. L., Rodríguez-Ramos, F. J., Priest, H., & Stokol, T. (2016). Holoprosencephaly and Pure Red Cell Aplasia in a Feline Leukaemia Virus-Positive Kitten. Journal of Comparative Pathology, 154(2-3), 239-242. https://doi.org/10.1016/j.jcpa.2016.01.006.

Szilasi, A., Dénes, L., & Balka, G. (2018). Feline Leukemia Virus (FeLV) Literature Review. Magyar Allatorvosok Lapja, 140(8), 457-472.

Tomiyasu, H., Doi, A., Chambers, J. K., Goto-Koshino, Y., Ohmi, A., Ohno, K., & Tsujimoto, H. (2018). Clinical and Clinic Pathological Characteristics of Acute Lymphoblastic Leukaemia in Six Cats. Journal of Small Animal Practice, 59(12), 742-746. https://doi.org/10.1111/jsap.12917.

Vail, D. M. (2016). Tumours of the Haemopoietic System. In J.M. Dobson & B. D. X. Lascelles (eds.). BSAVA Manual of Canine and Feline Oncology (third ed.) (pp. 285-303). India: BSAVA Parksons Graphics. https://doi.org/10.22233/9781905319749.19.1.

Vail, D. M. (2017). Hematopoietic Tumors. In S. J. Ettinger, E. C. Feldman & E. Coté (eds.). Textbook of Veterinary Internal Medicine (8th ed.) (pp. 5000-5032). St. Louis, Missouri: Elsevier.

Villiers, E. (2016). Disorders of Erythrocytes. In E. Villiers & J. Ristic (eds.). BSAVA Manual of Canine and Feline Clinical Pathology (third ed.) (pp. 38-66). Aberystwyth, United Kingdom: BSAVA. https://doi.org/10.22233/9781910443255.4.

Vobis, M., D’Haese, J., Mehlhorn, H., & Mencke, N. (2003). Evidence of Horizontal Transmission of Feline Leukemia Virus by the Cat Flea (Ctenocephalides felis). Parasitology Research, 91(6), 467-470. https://doi.org/10.1007/s00436-003-0949-8.

Westman, M. E., Malik, R., Hall, E., & Sheehy, P. A. (2017). Comparison of Three Feline Leukaemia Virus (FeLV) Point-of-Care Antigen Test Kits Using Blood and Saliva. Comparative Immunology, Microbiology and Infectious Diseases, 50, 88-96. https://doi.org/10.1016/j.cimid.2016.11.014.

White, R. N., & Brearley, M. (2016). Tumours of the Urogenital System. In J.M. Dobson & B. D. X. Lascelles (eds.). BSAVA Manual of Canine and Feline Oncology (third ed.) (pp. 248-264). India: BSAVA Parksons Graphics. https://doi.org/10.22233/9781905319749.17.

Wilkes, R. P., Kania, S. A., Tsai, Y. L., Lee, P. Y. A., Chang, H. H., Ma, L. J., Chang, H. F. G., & Wang, H. T. T. (2015). Rapid and Sensitive Detection of Feline Immunodeficiency Virus Using An Insulated Isothermal PCR-Based Assay with a Point-of-Need PCR Detection Platform. Journal of Veterinary Diagnosis Investigation, 27(4), 510-515. https://doi.org/10.1177/1040638715593597.



How to Cite

Canto-Valdés, M. C., Bolio-González, M. E., Ramírez-Álvarez, H., & Cen-Cen, C. J. (2019). Epidemiological, Clinical and Diagnostic Features of FeLV and FIV: An Updated Review. Ciencia Y Agricultura, 16(2), 57–77. https://doi.org/10.19053/01228420.v16.n2.2019.9119