Estudio de nuevos complejos metálicos derivados de un ligando flexible polidentado para aplicaciones biológicas y biomédicas

Study of novel metal complexes derived from a flexible polydentate ligand for biological and biomedical applications

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Dorian Polo

Resumen

El presente estudio muestra la obtención de 4 nuevos complejos lantánidos con iones Gd(III), Eu(III), Dy(III) y Yb(III), con dos ligandos polidentados F y L para evaluar su potencial aplicación en el contraste de imágenes para microscopía de fluorescencia (MF), resonancia magnética de imágenes (RMI) y como agentes antibacterianos. Se propone que los complejos poseen una estructura molecular en donde los ligandos quelan al centro metálico a través de los grupos -OH, -N- y -COO-, exhibiendo un aparente número de coordinación de 7. La relajatividad molar r1 muestra que los 4 complejos son capaces de acelerar el tiempo de relajación longitudinal T1 del agua, obteniéndose un r1 de 6.45 mmol-1·L-1·s-1 para el compuesto 1, el cual fue mayor que el valor 2.25 mmol-1·L-1·s-1 para el Dotarem® usado como medicamento de referencia en RMI. Los rendimientos cuánticos en referencia a la fluoresceína fueron menores al 1%, exhibiendo baja eficiencia en los procesos de emisión de radiación visible. Para los complejos se obtuvieron constantes de estabilidad aparente (-log[kap]) entre 21-18, siendo incluso mejores que algunos agentes de contraste. Finalmente, se confirmó que los complejos obtenidos logran unirse a las hebras del ADN a través de un posible mecanismo de intercalación.

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