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Vol. 13 No. 2 (2022)
Vol. 13 Núm. 2 (2022): Vol. 13 Núm. 2 (2022): Vol 13, Núm.2 (2022): Julio-Diciembre

Artículos de investigación / Research papers

Study of novel metal complexes derived from a flexible polydentate ligand for biological and biomedical applications

https://doi.org/10.19053/01217488.v13.n2.2022.14087

Published 2022-07-12

  • Juan-David Londoño-Mosquera
    • ,
  • Dorian Polo

Juan-David Londoño-Mosquera
Universidad del Valle

Dorian Polo
a:1:{s:5:"es_ES";s:21:"universidad del valle";}

Abstract

This work shows the synthesis of four new lanthanide complexes of Gd(III), Eu(III), Dy(III) and Yb(III) ions, using two polydentate ligands F and L in order to evaluate their potential application on the contrast-imaging by fluorescent microscopy (MF), nuclear magnetic resonance (RMI) and as antibacterial agents. We propose a structure where both ligands are bound to the metal centre through –OH, -N- and –COO- groups, exhibiting an apparent coordination number of 7. Moreover, r1 molar relaxivities obtained demonstrates that all the complexes had the capability to accelerate longitudinal relaxation times (T1) of water, with a r1 value of 6.45 mmol-1·L-1·s-1 for compound 1, which was higher than r1 of 2.25 mmol-1·L-1·s-1 corresponding to commercial drug Dotarem® employed for RMI. Furthermore, all quantum yields of fluorescence, in reference to fluorescein, where lower than 1%, showing a poor performance in emission processes of visible radiation. Stability constants determined as (-log[kap]) were between 21 and 18, being even better than some contrast agents. Finally, DNA binding experiments showed that all complexes had the capability to bind DNA strands by a possible intercalation mechanism.

Keywords

Polydentate ligand, Lanthanide ions, Contrast agent, Nuclear magnetic resonance, Fluorescent microscopy

PDF (Español)

Supplementary File(s)

Material Suplementario (Español)

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