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Vol. 7 Núm. 1 (2016)
Enero a Junio

Revisiones/Reviews

Optimal Population Designs for Discrimination Between Two Nested Nonlinear Mixed Effects Models.

https://doi.org/10.19053/01217488.4233

Publicado 2016-02-15

  • M. E. Castañeda L.
    • ,
  • V. I. López-Ríos

Resumen

In this paper we consider the problem of finding optimal population designs for discrimination between
two nested nonlinear mixed effects models which differ in their intra-individual covariance matrix. The
criterion proposed is a generalization of the T-optimality criterion. For this criterion an equivalence theorem is provided. The application of the criterion is illustrated with an example in pharmacokinetic.

 

Palabras clave

Optimal Designs, Mixed Effects Model, T-Optimal Designs. (Diseños T-óptimos, diseños óptimos, modelo de efectos mixtos.)

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Citas

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